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  • Funding Opportunities
  • Pharmacological Treatment for Anxiety...

Pharmacological Treatment for Anxiety Disorders in Children, Adolescents, and/or Young Adults - Cycle 1 2018

Letters of Intent were due Tuesday, February 13, 2018, by 5:00 p.m. ET.
Those selected to submit a full application were notified by Wednesday, March 14, 2018.
Full applications were due Wednesday, May 16, 2018, by 5:00 p.m. ET.


The Patient-Centered Outcomes Research Institute (PCORI) seeks to fund high-quality clinical studies that compare the effectiveness of two or more pharmacological treatments for moderate to severe anxiety in children, adolescents, and/or young adults (e.g., comparisons of shorter-acting to longer-acting selective serotonin reuptake inhibitors (SSRIs) or comparisons of SSRIs to selective serotonin norepinephrine reuptake inhibitors (SNRIs)); pharmacological treatments should be delivered in conjunction with cognitive behavioral therapy (CBT) or another evidence-based psychological intervention. 

For this PFA, PCORI is broadly interested in comparisons that are relevant and applicable to patients in the age range of 7 through 25 years; this age range represents a spectrum of developmental stages. Applicants will be asked to clearly define the specific age range to be studied, and to provide a scientific rationale justifying the coherence of the proposed study population, in terms of age, disease severity, proposed intervention approaches, and analytic plans.

Each proposed comparator must be clearly defined, evidence-based, and widely available, and applicants should ensure that all comparators are appropriate for the age range and disorder severity of the study population. Studies must include a minimum follow-up period of one year from baseline; two years of follow-up from baseline is preferred. In addition, all studies funded through this initiative must include robust sample sizes of at least 300 participants, with sufficient power demonstrated to conduct proposed primary analyses and subgroups as appropriate to the proposed population.

Note that this funding program does not support applications to conduct cost-effectiveness analyses, systematic reviews (with or without meta-analyses), or developing or evaluating shared decision-making or decision-support tools. In general, PCORI will not cover costs for interventions that are being compared in the proposed study (See Appendix 3 in the Application Guidelines for details).

Key Information
Status 
Closed
Cycle 
Cycle 1 2018
Full Announcement 
PDF icon Pediatric Anxiety PFA: Cycle 1 2018
Online System Opens 
January 16, 2018
Letter of Intent (LOI) Deadline
February 13, 2018 by 5 p.m. (ET)
Application Deadline
May 16, 2018 by 5 p.m. (ET)
Merit Review 
August 2018
Applicant Town Hall Session 

January 31, 2018; 12:00 p.m. (ET)

Earliest Start Date 
February 2019
Total Direct Costs 
$15 million
Funds Available Up To 
Up to $40 million
Maximum Project Period 
5 years
Announcement Type 
Research Award

Applicant Resources

  • Pediatric Anxiety PFA
  • Pediatric Anxiety Application Guidelines

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Research & Results

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  • Influencing the Culture of Research
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  • What & Who We Fund
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Meetings & Events

February 2
PCORI 2021 and Beyond: Opportunities for Funding and Involvement in Patient-Centered Research
February 9
Board of Governors Meeting: February 9, 2021
February 11
Advisory Panel on Patient Engagement Winter 2021 Meeting

PCORI

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Patient-Centered Outcomes
Research Institute

1828 L Street, NW, Suite 900
Washington, DC 20036
Phone: (202) 827-7700 | Fax: (202) 355-9558
[email protected]

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