|This PCORI Funding Announcement will open on Tuesday, January 5, 2021, with more information about the funding opportunity.|
Notice of Upcoming PCORI Funding Announcement
PCORI will issue a Funding Announcement in Cycle 1 2021 for Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes. This PFA emphasizes relevant Methodology Standards and the PCORI Guidance on the Design and Conduct of Trials in Real-World Settings.
PCORI seeks to fund clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; or eliminating health or healthcare disparities. Randomized study designs are strongly encouraged but not required.
Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, or delivery systems. They must involve broadly representative patient populations and be large enough to provide precise estimates of hypothesized effectiveness differences and to support evaluation of potential differences in treatment effectiveness in patient subgroups.
Available funding for Cycle 1 2021 PCS PFA will be $90 million and allow individual awards with budgets up to $10 million in direct costs and with a maximum project duration of five years.
This PFA preannouncement is provided to allow applicants additional time to identify collaborators, obtain stakeholder input on the research question, and develop responsive, high-quality proposals. Further details will be available in the full announcement.
*Please note that an earlier version of this preannouncement included communication and dissemination research and the former Cycle 1 2018 Pragmatic Clinical Studies PFA. This was corrected on December 1, 2020.