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  • Funding Opportunities
  • Pragmatic Clinical Studies to Evaluat...

Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes - Cycle 3 2017

Letters of Intent for this PCORI funding announcement were due Tuesday, October 31, 2017.
Those selected to submit a full application will be notified by Tuesday, November 28, 2017.
Full applications were due on Tuesday, February 6, 2018, by 5:00 pm ET.


PCORI seeks to fund pragmatic clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; communicating or disseminating research results to patients, caregivers, or clinicians; or eliminating health or healthcare disparities.

Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, or delivery systems. They must involve broadly representative patient populations and be large enough to provide precise estimates of hypothesized effectiveness differences and to support evaluation of potential differences in treatment effectiveness in patient subgroups.

PCORI’s multi-stakeholder panels have identified 16 high-priority topics and research questions. (See Appendix for list.) PCORI will give first consideration to applications that directly address one or more of the 16 PCORI identified topics. Note that PCORI is open to receiving and reviewing LOIs for studies on investigator-initiated CER questions as well.

Note that this funding program does not support applications to conduct cost-effectiveness analyses, systematic reviews (with or without meta-analyses), or developing or evaluating shared decision-making or decision-support tools. In general, PCORI will not cover costs for interventions that are being compared in the proposed study. (See Appendix 3 in the Application Guidelines for details.)

This announcement is a collaborative effort of PCORI’s Comparative Clinical Effectiveness Research, Communication and Dissemination Research, Improving Healthcare Systems, and Addressing Disparities research programs.

Key Information
Status 
Closed
Cycle 
Cycle 3 2017
Full Announcement 
PDF icon Pragmatic Clinical Studies PFA - Cycle 3 2017
Online System Opens 
October 3, 2017
Letter of Intent (LOI) Deadline
October 31, 2017 by 5 p.m. (ET)
Application Deadline
February 6, 2018 by 5 p.m. (ET)
Merit Review 
April 2018
Awards Announced 

August 21, 2018; 12:00 p.m. (ET)

Applicant Town Hall Session 

October 17, 2017; 12:00 p.m. (ET)

Earliest Start Date 
October 2018
Total Direct Costs 
$10 million
Funds Available Up To 
Up to $90 million
Maximum Project Period 
5 years
Announcement Type 
Research Award

Applicant Resources

  • Pragmatic Clinical Studies PFA (Cycle 3 2017)
  • Pragmatic Clinical Studies Application Guidelines (Cycle 3 2017)

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Research & Results

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  • Research Results Highlights
  • Putting Evidence to Work
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  • The Value of Engagement
  • Engagement in Health Research Literature Explorer
  • Influencing the Culture of Research
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Meetings & Events

April 12
Engagement Awards 2021 Special Cycle -- Applicant Office Hours (Three)
April 13
Board of Governors Meeting: April 13, 2021
April 19
Increasing Vaccine Confidence among Long-Term Care Workers: Expedited COVID-19 PFA -- Applicant Town Hall

PCORI

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Patient-Centered Outcomes
Research Institute

1828 L Street, NW, Suite 900
Washington, DC 20036
Phone: (202) 827-7700 | Fax: (202) 355-9558
info@pcori.org

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