Suicide rates in the US have been increasing during the past two decades, and there is concern that the economic, social, and psychological effects of the COVID 19 epidemic will lead to a further rise in suicide rates. Increasing rates for youth have caused specific concern.

PCORI seeks to fund large randomized controlled trials (RCTs) and/or observational studies that respond to the following question: What is the comparative effectiveness of different brief interventions to reduce suicidality and improve outcomes for youth ages 15 to 24?

Each proposed Brief Intervention must be clearly defined, evidence-based or in clinical use, and be, or be able to be made, widely available. Brief Interventions should be designed to reduce acute suicide risk and direct patients to appropriate treatment, and should be deliverable in a variety of settings and by a range of healthcare professionals.

PCORI is particularly interested in the comparative effectiveness of culturally adapted approaches to brief interventions for specific populations. Such adaptations should address barriers to effective patient-centered care for these populations. Cultural adaptation may include involvement of people with lived experience, telehealth, cultural contexts, specific settings, or other cultural factors.

Proposals should have strong endorsement and study participation by people with lived experience, patient organizations, professional organizations, payer or purchaser organizations, and/or other relevant stakeholder groups.

Reminder: The primary institution’s Administrative Official must review, authorize, and submit the full application by 5pm EST on January 12, 2021.

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Key Dates

Online System Opens
September 1, 2020, 12:00 AM
Letter of Intent Deadline
September 29, 2020, 12:00 AM
Application Deadline
January 12, 2021, 12:00 AM
Awards Announced
<p><a href="/node/19541">July 27, 2021; 1:00pm - 2:30pm (ET)</a></p>

Funds and Project Period

Funds Available Up To

$30 million

Total Direct Costs

Up to $10 million

Maximum Project Period

5 years


Award Types