Cycle 1 2021
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
- Optimizing Infrastructure for Conducting Patient-Centered Outcomes Research: PCORnet, The National Patient-Centered Clinical Research Network -- Phase 3
Cycle 3 2020
- Phased Large Awards for Comparative Effectiveness Research (PLACER)
- Suicide Prevention: Brief Interventions for Youth
- Broad PCORI Funding Announcements (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Implementation of Findings from PCORI's Major Research Investments (IMRI)
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
Cycle 2 2020
- COVID-19 Targeted PFA
- Implementation of Effective Shared Decision Making Approaches in Practice Settings
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
- Limited Competition PCORI Funding Announcement: Conducting Rare Disease Research using PCORnet®
- Observational Analyses of Second-Line Pharmacological Agents in Type 2 Diabetes
Cycle 1 2020
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
Cycle 3 2019
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
Cycle 2 2019
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
- Implementation of Effective Shared Decision Making Approaches in Practice Settings
- Treatment Options for Age-Related Hearing Loss
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
Cycle 1 2019
- Treatment of Posttraumatic Stress Disorder (PTSD) in Adults
- Treatment Options for Age-Related Hearing Loss
- Treatment of Anxiety in Children, Adolescents, and/or Young Adults
- Limited PCORI Funding Announcement: Partnerships to Conduct Research within PCORnet (PaCR)
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
- Implementation of Findings from PCORI's Major Research Investments (IMRI)
Cycle 3 2018
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
Cycle 2 2018
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Psychosocial Interventions with Office-Based Opioid Treatment for Opioid Use Disorder
- Symptom Management for Patients with Advanced Illness
- Medication-Assisted Treatment (MAT) Delivery for Pregnant Women with Substance Use Disorders Involving Prescription Opioids and/or Heroin
- Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
- Implementation of Effective Shared Decision Making Approaches in Practice Settings
Cycle 1 2018
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
- Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
- Pharmacological Treatment for Anxiety Disorders in Children, Adolescents, and/or Young Adults - Cycle 1 2018
Cycle 3 2017
- Broads (for Addressing Disparities, Assessment of Options, Communication and Dissemination Research, Improving Healthcare Systems)
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
- Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
Cycle 2 2017
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
- Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
- Symptom Management for Patients with Advanced Illness
- Medication-Assisted Treatment (MAT) Delivery for Pregnant Women with Substance Use Disorders Involving Prescription Opioids and/or Heroin
- Limited PCORI Funding Announcement: Partnerships to Conduct Research within PCORnet (PaCR)
- Strategies to Prevent Unsafe Opioid Prescribing in Primary Care among Patients with Acute or Chronic Noncancer Pain
- Implementation of Effective Shared Decision Making Approaches in Practice Settings
Cycle 1 2017
- Broads
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
- Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
- Comparison of Surgical and Nonsurgical Options for Management of Chronic Nonspecific Low Back Pain
- Optimized Multidisciplinary Treatment Programs for Nonspecific Chronic Low Back Pain
Cycle 3 2016
- Broads
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
- Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
- Community-Based Palliative Care Delivery for Adult Patients with Advanced Illnesses and their Caregivers
- Strategies to Prevent Unsafe Opioid Prescribing in Primary Care among Patients with Acute or Chronic Non-Cancer Pain
- Management of Care Transitions for Emerging Adults with Sickle Cell Disease
- Treatment of Multiple Sclerosis
- Clinical Strategies for Managing and Reducing Long-Term Opioid Use for Chronic Pain
Cycle 2 2016
- Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
- Comparison of Surgical and Nonsurgical Options for Management of Nonspecific Chronic Low Back Pain
Cycle 1 2016
- Broads
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Limited PCORI Funding Announcement: Dissemination and Implementation of PCORI Funded Patient-Centered Outcomes Research Results and Products in Real World Settings
Limited PCORI 2016 Funding Announcement: Health Systems PCORnet Demonstration Project
Patient-Powered Research Network (PPRN) Research Demonstration Project: A Cross-PPRN Opportunity
The National Patient-Centered Clinical Research Network (PCORnet): Initiative on Health Plan/System Data Partnerships (A Stepwise Approach to Collaboration)
Cycle 3 2015
- Broads
- Improving Methods for Conducting Patient-Centered Outcomes Research
- Pragmatic Clinical Studies To Evaluate Patient-Centered Outcomes
- Clinical Strategies for Managing and Reducing Long-Term Opioid Use for Chronic Pain
- Management Strategies for Treatment-Resistant Depression
- New Oral Anticoagulants (NOACs) in the Extended Treatment of Venous Thromboembolic Disease
- Treatment of Multiple Sclerosis
Cycle 2 2015
- Broads
- Improving Methods for Conducting Patient-Centered Outcomes Research
Patient-Powered Research Networks (PPRN) Research Demonstration Projects
The Natural Experiments Network: A Collaborative Initiative
Large Pragmatic Studies to Evaluate Patient-Centered Outcomes (Spring 2015 Cycle)
Spring 2015 Cycle
- Application Guidelines
- Improving Methods Application Guidelines
- Addressing Disparities Funding Announcement
- Assessment of Prevention, Diagnosis, and Treatment Options Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Improving Methods for Conducting Patient-Centered Outcomes Research Funding Announcement
Patient-Centered Outcomes Research (PCOR) for Treatment Options in Uterine Fibroids: Developing a Prospective Multi-Center Practice-based Clinical Registry (P50)
Clinical Management of Hepatitis C Infection
Testing Multi-Level Interventions to Improve Blood Pressure Control in Minority Racial/Ethnic, Low Socioeconomic Status, and/or Rural Populations (UH2/UH3)
- Request for Applications (RFA) Announcement (RFA-HL-15-021)*
- U24/To Support the Coordinating Function for This Award (RFA-HL-15-031)
* This RFA announcement was administered by the National Heart, Lung and Blood Institute (NHLBI) at NIH, the National Institute of Neurological Disorders and Stroke (NINDS), and PCORI, with funds provided by PCORI to NIH.
Obesity Observational Research Initiative
Large Pragmatic Studies to Evaluate Patient-Centered Outcomes (Winter 2015 Cycle)
PCORnet: Clinical Data Research Networks (CDRN) & Patient Powered Research Networks (PPRN)—Phase II
Optimal Maintenance Aspirin Dose for Patients with Coronary Artery Disease (Limited PFA) [Winter 2015]
Large Pragmatic Studies to Evaluate Patient-Centered Outcomes (Fall 2014 Cycle)
Fall 2014 Cycle
- Application Guidelines
- Improving Methods Application Guidelines
- Addressing Disparities Funding Announcement
- Assessment of Prevention, Diagnosis, and Treatment Options Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Improving Methods for Conducting Patient-Centered Outcomes Research Funding Announcement
Engagement Award (EAIN): Supporting Dissemination and Implementation Activities of the PCORI Pilot Projects Learning Network (PPPLN)
- Funding Announcement*
*This was a one-time funding opportunity to support the dissemination and implementation activities for the PCORI Pilot Projects and the PCORI Pilot Projects Learning Network.
Pragmatic Clinical Studies and Large Simple Trials (Spring 2014)
Spring 2014 Cycle
- Application Guidelines
- Improving Methods Application Guidelines
- Addressing Disparities Funding Announcement
- Assessment of Prevention, Diagnosis, and Treatment Options Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Improving Methods for Conducting Patient-Centered Outcomes Research Funding Announcement
The Effectiveness of Transitional Care (Spring 2014)
Obesity Treatment Options Set in Primary Care for Underserved Populations
Winter 2014 Cycle
- Application Guidelines
- Improving Methods Application Guidelines
- Addressing Disparities Funding Announcement
- Assessment of Prevention, Diagnosis, and Treatment Options Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Improving Methods for Conducting Patient-Centered Outcomes Research Funding Announcement
Clinical Trial of a Multifactorial Fall Injury Prevention Strategy in Older Persons (U01)
*This funding opportunity is being administered by the National Institute on Aging.
August 2013 Cycle
- Application Guidelines
- Assessment Prevention Diagnosis Treatment Options Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Addressing Disparities Funding Announcement
- Improving Methods for Conducting Patient-Centered Outcomes Research Funding Announcement
Asthma
Infrastructure
Cycle III and Improving Methods Inaugural Cycle
- Application Guidelines
- Assessment of Prevention Diagnosis and Treatment Options Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Addressing Disparities Funding Announcement
- Improving Methods for Conducting Patient-Centered Outcomes Research Funding Announcement
Cycle II
- Application Guidelines
- Assessment of Prevention, Diagnosis, and Treatment Options Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Addressing Disparities Funding Announcement
Cycle I
- Application Guidelines
- Assessment of Prevention, Diagnosis, and Treatment Options Funding Announcement
- Improving Healthcare Systems Funding Announcement
- Communication and Dissemination Research Funding Announcement
- Addressing Disparities Funding Announcement
Pilot Projects
Reporting Templates
^The purpose of the final report is to:
- Provide an update on the last six months of your project
- Provide an overall recap of your pilot project, including main study findings, impact, dissemination plans, and next steps
- Provide information for Peer Review of your funded work
Additional Resources
PFA Cycles
Cycle 1 2021 | Cycle 3 2020 | Cycle 2 2020 | Cycle 1 2020 | Cycle 3 2019 | Cycle 2 2019 | Cycle 1 2019 | Cycle 3 2018 | Cycle 2 2018 | Cycle 1 2018 | Cycle 3 2017 | Cycle 2 2017 | Cycle 1 2017 | Cycle 3 2016 | Cycle 2 2016 | Cycle 1 2016 | Health Systems PCORnet Demonstration Project | PPRN Research Demonstration Project: A Cross-PPRN Opportunity | PCORnet Initiative on Health Plan/System Data Partnerships | Cycle 3 2015 | Cycle 2 2015 | PPRN Research Demonstration Projects | The Natural Experiments Network | Large Pragmatic Studies (Spring 2015) | Spring 2015 Cycle | PCOR for Treatment Options in Uterine Fibroids | Clinical Management of Hepatitis C Infection | Testing Multi-Level Interventions to Improve Blood Pressure Control | Obesity Observational Research Initiative | Large Pragmatic Studies (Winter 2015) | PCORnet CDRN/PPRN Phase II | Optimal Maintenance Aspirin Dose | Large Pragmatic Studies (Fall 2014) | Fall 2014 Cycle | Pragmatic Clinical Studies and Large Simple Trials (Spring 2014) | Spring 2014 Cycle | The Effectiveness of Transitional Care (Spring 2014) | Winter 2014 Cycle | Obesity Treatment Options Set in Primary Care for Underserved Populations | Clinical Trial of a Multifactorial Fall Injury Prevention Strategy in Older Persons | August 2013 Cycle | Asthma | Infrastructure | Cycle III and Improving Methods Inaugural Cycle | Cycle II | Cycle I | Pilot Projects