PCORI Funding Announcements (PFAs) seek applications for patient-centered comparative clinical effectiveness research projects on a variety of topics that address needs of patients, caregivers, clinicians, and other healthcare stakeholders. Below are the Merit Review Criteria for each PFA and a video highlighting some of them.

Broad PFA

  • Addressing Disparities
  • Assessment of Prevention, Diagnosis, and Treatment Options
  • Communication and Dissemination Research
  • Improving Healthcare Systems

Targeted PFA

Click here to view the entire PFA (including the criteria)

  • Comparative Effectiveness of Multimodal Interventions to Prevent Osteoporotic Fractures
  • Healthy Aging: Optimizing Physical and Mental Functioning Across the Aging Continuum
  • Comparative Effectiveness of Novel Pharmacologic and Evidence-Based Nonpharmacologic Treatments for Migraine Prevention

Improving Methods PFA

  • Improving Methods for Conducting Patient-Centered Outcomes Research

Implementation PFA

  • Implementation of PCORI-Funded Patient-Centered Outcomes Research Results
  • Implementation of Findings from PCORI's Major Research Investments 
  • Implementation of Effective Shared Decision Making Approaches in Practice Settings

Pragmatic Clinical Studies PFA

  • Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes


  • Phased Large Awards for Comparative Effectiveness Research

About PCORI's Merit Review Criteria

Full applications submitted to PCORI are reviewed against six merit review criteria. The evaluation of how well the application addresses these criteria help determine which applications have the greatest potential to provide evidence that will help patients and other stakeholders make better healthcare decisions. See the video for more information.

Posted: February 15, 2019; Updated: October 4, 2021

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