Research Focus
Comparative Clinical Effectiveness Research (CER)
Studies that compare outcomes to determine the effectiveness, including risks and benefits, of two or more approaches to health care
Upcoming Targeted PCORI Funding Announcements
Opening Tuesday, April 13, 2021
Opening Tuesday, May 4, 2021
- Improving Postpartum Maternal Outcomes for Populations Experiencing Disparities -- Cycle 2 2021
- Nonsurgical Options for Women with Urinary Incontinence -- Cycle 2 2021
- Comparative Effectiveness of Interventions Targeting Mental Health Conditions in Individuals with Intellectual and Developmental Disabilities -- Cycle 2 2021
CER Methods and Infrastructure
Studies to improve the methods available for patient-centered CER
Development of a large, highly representative electronic-data infrastructure called PCORnet®, The National Patient-Centered Clinical Research Network, for improving the conduct of patient-centered CER
Conditions Studied
We pay particular attention to:
- Conditions that affect large numbers of people across a range of populations
- Conditions that place a heavy burden on individuals, families, specific populations, and society
- Rare diseases, which are difficult to study
Populations of Interest
We pay particular attention to a number of populations in making research funding decisions:
- Racial and ethnic minorities
- Older adults
- Low-income
- Residents of rural areas
- Women
- Children
- Individuals with special healthcare needs, including individuals with disabilities, individuals with multiple chronic diseases, individuals with rare diseases, and individuals whose genetic makeup affects their medical outcomes
- Patients with low health literacy/numeracy and limited English proficiency
- Lesbian, gay, bisexual, transgender (LGBT) persons
- Veterans and members of the armed forces and their families
Eligibility
Private Sector
- Nonprofit research organizations
- For-profit research organizations
Public Sector
- Universities and colleges
- Hospitals and healthcare systems
- Laboratories and manufacturers
- Units of state, local, or federal government
US Organizations
Must be recognized by the Internal Revenue Service
Foreign Organizations and Nondomestic Components of US Organizations
May apply if:
- There is demonstrable benefit to the US healthcare system, and the essential scientific needs will be met by conducting the study outside the United States or having the study conducted by non-US research organizations
- US efforts in the area of patient-centered research can be clearly shown, and the engagement plans include US patients and stakeholders, and are relevant to US healthcare system
Individuals
Not permitted to apply
Posted: September 2014; Updated: April 2021