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Funding Applications Encouraged Around Topic Themes

In July 2022, PCORI's Board of Governors approved a set of eight broad topic themes that will inform PCORI’s focused funding opportunities over the next several funding cycles.

The themes speak to health issues facing large numbers of Americans including children, youth, and older adults and address urgent topics such as violence and trauma, substance use, and mental and behavioral health, as well as widespread conditions including cardiovascular disease, pain management, and sleep health. These themes arose from a wealth of public input received from a broad spectrum of stakeholders during PCORI’s recent strategic planning effort and include many challenges ripe for patient-centered comparative effectiveness research.

The themes are intentionally broad, and additional stakeholder engagement will drive further refinement of the themes over time. We encourage but do not limit submissions to those aligned to these topic themes. Applicants may continue to propose projects that do not directly align with the themes as long as they fit within our core mission of patient-engaged and patient-centered comparative clinical effectiveness research and our National Priorities for Health.

In addition, PCORI also seeks applications related to four ongoing key topics—improving outcomes for people with intellectual and developmental disabilities, preventing maternal morbidity and mortality, COVID-19, and rare disease. The examples below illustrate the breadth of issues that could fall under each topic theme and are intended to serve as springboards for applicant idea generation. Learn more about the broad stakeholder input that informed development of these topic themes.

Populations

These examples serve as illustrations only and are intended to demonstrate the breadth of issues that could fall under these topic themes.


Promoting healthy children and youth

  • Approaches to improve mental health care and crisis prevention for children and youth
  • Approaches to support healthy weight management
  • Interventions to improve physical and mental health outcomes for youth with intellectual and/or developmental disabilities
  • Interventions to support caregivers of children and youth with chronic illness
  • Interventions to support vaccine confidence and uptake
  • Models of care for children transitioning to adult care with complex medical conditions, including rare diseases

Promoting health for older adults

  • Approaches to screen, diagnose, treat, or manage dementia
  • Approaches to screen, treat, or manage eye conditions associated with visual impairment
  • Care models to facilitate coordination between primary and specialty care and community resources for older adults with multiple chronic conditions
  • Interventions to address loneliness and social isolation
  • Interventions to support caregivers of individuals with dementia and other serious illnesses

Health Behavior

These examples serve as illustrations only and are intended to demonstrate the breadth of issues that could fall under these topic themes.


Addressing violence and trauma

  • Community-based interventions to address existing structural and/or social determinants of health to prevent violence
  • Interventions to improve quality of life and access to care for individuals with post-traumatic stress disorder
  • Models of trauma-informed care to optimize health outcomes
  • Systems-based approaches to identify and support individuals experiencing interpersonal violence, such as intimate partner violence, child abuse, or elder abuse

Addressing substance use

  • Approaches to address barriers to effective treatments for substance use
  • Prevention, identification, and treatment of substance use, including nicotine, in youth
  • Strategies to prevent overdose in at-risk populations
  • Treatment of coexisting substance use and mental health conditions
  • Treatment of substance use in adults across the aging continuum

Health Conditions

These examples serve as illustrations only and are intended to demonstrate the breadth of issues that could fall under these topic themes.


Improving cardiovascular health

  • Approaches to improve access and adherence to prevention treatments for individuals with cardiovascular disease
  • Prevention and treatment of hypertension during pregnancy and postpartum
  • Prevention strategies, risk factor reduction, and treatment approaches for cardiovascular conditions such as atherosclerotic disease, arrythmias, and heart failure
  • Treatment and management strategies for primary hypertension in children, adolescents, and younger adults

Managing pain

  • Approaches to address systemic and structural barriers to equitable access to effective pain management
  • Approaches to managing pain and other symptoms in chronic or advanced illness
  • Approaches to pain management in community-dwelling older adults
  • Prevention and treatment of chronic pain conditions such as migraine
  • Treatment interventions for acute pain

Promoting sleep health

  • Approaches to screen, treat, and deliver interventions for chronic insomnia
  • Approaches to screen, treat, and increase adherence to treatment for obstructive sleep apnea
  • Treatment of sleep disorders in individuals with intellectual and/or developmental disabilities and other understudied populations

Improving mental and behavioral health

  • Approaches to addressing maternal mental health during pregnancy and in the postpartum period
  • Approaches to improve mental health care and crisis prevention
  • Systems-level interventions to address mental health and burnout in people who work in health care
  • Treatments to improve mental health outcomes for individuals with intellectual and/or developmental disabilities

Posted: December 9, 2022

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