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An infant of mixed race lies on a table in a clinic, while the hands of a medical professional is seen pressing a stethoscope on the infant's bare chest.

Uncontrolled seizures in children up to 36 months old have serious short-term health risks and may be associated with substantial developmental, behavioral, and psychological impairments.

A systematic review, Management of Infantile Epilepsies, supported by PCORI through a research partnership with the Agency for Healthcare Research and Quality, evaluates the effectiveness, comparative effectiveness, and harms of several treatments for infantile epilepsies.

The main findings of the review include the following: Levetiracetam may be effective in increasing seizure freedom. Ketogenic and modified Atkins diets may reduce seizure frequency. Surgical procedures (Hemispherectomy/Hemispherotomy and Non-Hemispheric procedures) may lead to seizure freedom in some infants.

View the Systematic Review Report


Posted: November 2, 2022

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