Emerging Health Care Innovation Brief: Treatments for Alcohol Use Disorder and a Autonomic Nervous System Disorder (March 2-15, 2023)
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Highlights
Highlights provide a timely synopsis of selected interesting developments emerging in the last two weeks from the information universe covered by the PCORI Health Care Horizon Scanning System (HCHSS). Information covers currently emerging innovations in patient-centered care that may or may not be directly related to the Topics to Watch. The views presented here are solely those of ECRI Horizon Scanning and have not been vetted by other stakeholders.
The Third International Summit on Human Genome Editing, held March 6-8, 2023, concluded with a statement highlighting the potential of somatic human genome editing while calling out the need for investment in equitable access. The meeting showcased Victoria Gray’s remarkable recovery from sickle cell disease resulting from treatment with exagamglogene autotemcel (exa-cel, formerly CTX001), the CRISPR-enabled gene-edited stem cell therapy (see the PCORI Horizon Scanning Database for another gene therapy in development for sickle cell disease).
In COVID-19 developments, a recent study of metformin is raising hopes for possible prevention of post-COVID conditions (PCC or long COVID). The trial results (released as a preprint by The Lancet) show that metformin started within four days of COVID-19 symptoms and taken over two weeks reduced the relative risk of long COVID by 42 percent compared with placebo. Ivermectin and fluvoxamine, also tested in this quadruple-blind, parallel-group randomized trial, showed no statistical difference.
Prevention of long COVID is vital to both individuals and the health system. Studies continue to document the long-term troubles that arise from PCC—most recently, gastrointestinal and cardiovascular (see Topics to Watch for a potential new treatment of PCC fatigue, heart palpitations, light-headedness, headache and nausea caused by a dysregulated heart rate).
Topics to Watch
ECRI Horizon Scanning has selected the topics below as those with potential for impact within the PCORI HCHSS’s focus areas in the United States within the next three years. All views presented are preliminary and based on readily available information at the time of writing. Because these topics are rapidly developing, we cannot guarantee the accuracy of this information after the date listed on this publication. In addition, all views expressed in the commentary section are solely those of ECRI Horizon Scanning and have not been vetted by other stakeholders. Topics are listed in alphabetical order.
Apremilast (Otelzla) to Treat Alcohol Use Disorder
At a Glance
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For a description and commentary about this topic/issue, download this Innovation Brief.
Efgartigimod (Vyvgart) to Treat Post-COVID Postural Orthostatic Tachycardia Syndrome
At a Glance
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For a description and commentary about this topic/issue, download this Innovation Brief.
Horizon scanning is a systematic process that serves as an early alert system to inform decision makers about possible future opportunities and threats. Health care horizon scanning identifies technologies, innovations, and trends with the potential to cause future shifts or disruptions—positive or negative—in areas such as access to care, care delivery processes, care setting, costs of care, current treatment models or paradigms, health disparities, health care infrastructure, public health, and patient health outcomes.
The PCORI Health Care Horizon Scanning System (HCHSS) conducts horizon scanning to better inform research investments at the Patient-Centered Outcomes Research Institute (PCORI). PCORI defines the HCHSS project scope to focus on interventions with high potential for disruption in the United States in the next 12 months within 6 focus areas: Alzheimer’s disease and other dementias, cancer, cardiovascular diseases, infectious diseases (including COVID-19), mental and behavioral health conditions, and rare diseases. In addition, the system captures high-level disruptive trends across all clinical areas, which may lead PCORI to expand the project scope to include other focus areas in the future.
The HCHSS produces 3 main outputs:
- Emerging Health Care Innovation Brief provides ECRI Horizon Scanning with a vehicle to inform PCORI and the public in a timely manner of important topics of interest identified during ongoing scanning and topic identification or through the ECRI stakeholder survey process.
- PCORI’s Horizon Scanning Database offers health care decision makers findings about advancements in the HCHSS’s 6 focus areas. This database can be used by patients, care partners, and others to track advancements in care options.
- High Potential Disruption Reports (every 6 months) for individuals with vested interests in new technologies, services, and innovations. It might provide critical insights and information about the areas in which they have a vested interest, which might include their vision and plans for how they intend to adopt an innovation. These reports highlight those topics that stakeholders (eg, patients, physicians, nurses, allied health professionals, public health professionals, first responders, health systems experts, clinical engineers, researchers, business and finance professionals, and information technology professionals) identified as having potential for high disruption.
In January 2023, the HCHSS Biweekly COVID-19 Scans were broadened in scope to include any emerging intervention in the HCHSS and renamed as the Emerging Health Care Innovation Brief.
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Posted: March 24, 2023
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