Drugs & Devices for Migraine Prevention
Migraine headache is a disabling condition that one in six Americans experience. Although many interventions for migraine prevention have shown to be effective, decision making for patients and physicians can be complex. Most pharmacologic therapies commonly used for migraine prevention were originally developed for treatment of other medical conditions such as hypertension, epilepsy, or depression. This project assesses the efficacy, tolerability, and side effects of traditional therapies for migraine prevention alongside newer therapies to inform decisions and identify evidence gaps.
This evidence visualization and corresponding report summarize the findings from a systematic rapid review of all randomized controlled trials of drugs and devices used for migraine prevention. Overall, 203 trials are represented in three interactive evidence visualizations:
- Map 1: Assesses effectiveness of 15 drugs and 2 devices for migraine reduction, tolerability, and reported harms from 78 placebo or sham-controlled trials.
- Map 2: Visualizes existing studies of placebo or sham-controlled randomized clinical trials drugs and devices for migraine prevention.
- Map 3: Visualizes existing studies of head-to-head comparative randomized clinical trials on drugs and devices for migraine prevention.
Methodology (Summary Report)
View the summary report for this evidence visualization.
Tsou A, Rouse B, Bloschichak a, et al. Drugs and Devices for Migraine Prevention: Interactive Evidence Maps. Patient-Centered Outcomes Research Institute; February 2021. Prepared by ECRI under Contract No. IDIQ-TO#12-ECRI-SCI-EVIDENCEMAP-2019-07-15.
View more details about the project here.
Visualizing the Benefits and Harms of Drugs and Devices for Migraine Prevention
Migraine headache affects one in six Americans. For some people who live with them, migraines are a disabling condition. We’ve developed an evidence map, visualization, and report to help patients and healthcare professionals understand the results of studies on the many treatments available.
Please take a brief, anonymous survey about your experience with this evidence map and visualization.
Your feedback will help PCORI staff improve our online tools.
Questions or comments about this evidence map and visualization? Contact the PCORI Research Synthesis team
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