These reports also identify gaps that need to be addressed for the technologies or therapeutics to move forward.

Genomic Sequencing to Guide Cancer Management

This review of commercially available next-generation sequencing tests for cancer management includes 321 published clinical research studies reporting on a variety of outcome measures, including identification of actionable mutations, patient management decisions, and patient health outcomes.

View Report

Narrative Review and Evidence Mapping of Artificial Intelligence in Clinical Care

From self-driving cars to smart supply chains, artificial intelligence (AI) has already changed many aspects of human life. Some areas of health care, such as medical imaging, are benefiting from AI, but questions remain on the role of AI in the broader health sector. Recognizing the importance of this emerging technology and the potential of AI to improve health for all, this report focuses on applications of AI in health that are currently in use or may be in use in the near future.

View Narrative Review and Evidence Map

Issue Brief on Artificial Intelligence in Clinical Care

This four-page document spotlights information from the Narrative Review and Evidence Map on Artificial Intelligence (AI) in Clinical Care. The issue brief describes AI applications currently in use and on the horizon, evidence for AI in clinical medicine, and challenges and opportunities ahead.

View Issue Brief

Narrative Review and Evidence Mapping of Proteomics for Cancer and Cardiovascular Disease

Clinical proteomics offers the promise of more precise risk assessment, diagnosis, and prognosis of disease. Proteomic testing has been proposed for a wide variety of applications and conditions. This report offers a narrative review and evidence maps for proteomics for cancer and cardiovascular disease.

View Narrative Review

Issue Brief on Proteomics for Cancer and Cardiovascular Disease

This three-page document spotlights information from the Narrative Review and Evidence Mapping of Proteomics for Cancer and Cardiovascular Disease. The issue brief describes proteomic applications currently in use and on the horizon, evidence for proteomics in clinical medicine, and challenges ahead.

View Issue Brief

Landscape Review and Evidence Map of Gene Therapy

Gene therapy has evolved rapidly and may be poised to affect mainstream medicine. Gene therapy initially targeted incurable genetic diseases (e.g., metabolic diseases), but indications have now expanded, and now the most commonly used applications are to treat certain cancers. In response to the increase in approved gene therapy approaches, PCORI commissioned this landscape review. The purpose of this report is to better understand the evidence supporting currently approved gene therapies and those that may be available in the near term in the United States. Because the literature base across all of the interventions is so large, we split the content into 2 parts.

Issue Brief on Gene Therapy in 2019: Milestones and Challenges

This four-page document spotlights information from the Landscape Review and Evidence Map of Gene Therapy. The issue brief discusses approved therapies and those on the horizon, as well as the challenges and opportunities ahead.

View Issue Brief

B-cell Lymphoma and Non-Hodgkin’s Lymphoma Treatment: How Do Participants of Chimeric Antigen Receptor T-cell Therapy Research Studies Compare With Patients in the US Population?

Human gene therapy has evolved rapidly, and chimeric antigen receptor T-cell (CAR-T) therapy appears to be a promising treatment for B-cell lymphoma and non-Hodgkin’s lymphoma. This report compares participants of CAR-T therapy research studies to individuals living with the diseases in the US population.

View Report


Posted: June 11, 2019; Updated: August 23, 2021

What's Happening at PCORI?

The Patient-Centered Outcomes Research Institute sends weekly emails highlighting results of our funded studies, newly funded research and engagement awards, opportunities to apply for funding, stakeholder workshops, and original feature stories about our funded projects.

Sign Up for Updates

Image

Hand pointing to email icon