Evidence Maps on Treatments for Fatigue in MS

A broad range of fatigue interventions for multiple sclerosis (MS) exists, including drugs, exercise, cognitive behavioral therapy, self-management strategies, and non-invasive brain stimulation. However, important questions remain regarding efficacy. The development of these evidence maps involved a systematic identification of relevant research studies of fatigue interventions in MS, along with data extraction, meta-analyses, and strength of evidence ratings.

These maps were created, in part, to help patients and those who care for them make informed decisions for a condition with multiple interventions available that typically may be selected based on individual preference or individual characteristics. The maps were primarily developed as pilots, to explore various methodologic issues encountered in this emerging form of evidence synthesis.

For the best map interaction experience, we recommend viewing these evidence maps on desktop-sized devices in a Chrome, Safari, or Firefox browser.

Overview of All Study Designs for Multiple Sclerosis Fatigue Interventions

Benefits and Harms of Multiple Sclerosis Fatigue Interventions

Head-to-Head Comparisons of Frequently Used MS Fatigue Interventions

View the Summary Report

Posted: March 6, 2019

What's Happening at PCORI?

The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

Subscribe to PCORI Emails


Hand pointing to email icon