Using this information, PCORI evaluates the state of the research literature to determine if the current research supports development of a PCORI research product such as a systematic review or a primary research study. The reviews summarize the quality and quantity of research studies.

Nonpharmacologic Interventions for Migraine Prevention

Migraine is a common condition that is disabling for many Americans. Although pharmacologic therapies for migraine prevention exist, nonpharmacologic therapies are an important alternative.

In this Topic Brief, the authors identified 164 randomized controlled trials, 27 of which were not summarized by relevant systematic reviews. They concluded that a substantive evidence base for nonpharmacologic migraine prevention therapies exists and that nonpharmacologic interventions remain an important alternative to pharmacotherapy for patients.

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Infantile Epilepsy

Epilepsy is more common in children than adults, with several epilepsy syndromes exclusive to the pediatric population.

In this Topic Brief, the authors identified 401 relevant empirical studies reporting specifically on the effect of epilepsy treatment in children. They also sought to determine the amount of research evidence specific to those children three years old or younger.

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Enhanced Recovery After Surgery

Enhanced Recovery After Surgery (ERAS) protocols are interventions that seek to improve recovery after surgical procedures.

In this Topic Brief, the authors identified 947 completed or ongoing empirical studies addressing aspects of ERAS that varied in their applicability to vascular surgery. A total of 115 studies focused exclusively on vascular surgery patients and evaluated an aspect of ERAS.

View this Topic Brief


Posted: December 23, 2019; Updated: August 30, 2021

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