A female medical professional in blue scrubs pushes a wheelchair with an elderly Black male patient through the atrium of a hospital.
March 2023 Update: PCORI has selected 42 health systems to participate in HSII. View the HSII Participants

About HSII

Key Dates

  • Next HSII Learning Network Meeting
    June 9, 2023
  • Capacity Building Project Awards Announcement
    June 2023

The Health Systems Implementation Initiative (HSII) is a new multi-year PCORI initiative to advance the uptake of practice-changing comparative clinical effectiveness research results in care delivery settings.

Through HSII, PCORI will provide funding to HSII Participant healthcare delivery systems to undertake implementation projects to actively advance the adoption of new evidence. These projects will have the goal of promoting the uptake of specific PCORI-funded evidence in practice.

PCORI’s Board of Governors has committed an initial investment up to $50 million to support implementation under HSII.

HSII is intended to facilitate lasting change within participating systems and lay groundwork for broader adoption of evidence-based practices.

The HSII Participants

As of March 2, 2023

On March 2, 2023, PCORI announced the 42 health systems selected to participate in HSII. HSII Participants collectively represent 800 hospitals serving 79 million patients across 41 states and the District of Columbia.

They include academic medical centers, community-based systems, integrated healthcare delivery and finance systems, safety net health systems, faith-based systems, public healthcare delivery systems, and a medical center within the Veterans Health Administration.

View HSII Participants

Funding Opportunities

HSII Capacity Building Projects

For the first HSII funding opportunity, HSII Participants could submit Capacity Building Project Proposals to undertake work to enhance their ability to conduct successful implementation and program evaluation under HSII. Proposals for HSII Capacity Building Projects are now under PCORI review. Awards will be announced in June 2023.

Learn More View HSII FAQs

HSII Implementation Projects

Beginning Fall 2023, PCORI anticipates issuing Calls for Proposals for Implementation Projects, providing HSII Participants the opportunity to propose projects to promote the uptake of specific PCORI-funded evidence within their healthcare delivery settings.

Posted: November 4, 2021; Updated: April 10, 2023

What's Happening at PCORI?

The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

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