This collection of journal publications provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Comparing Ways to Manage Asthma in African-American Children
Results from The ASIST Study support existing evidence that children with mild asthma can self-manage their condition by using medications when their symptoms occur. This contrasts with the traditional method of taking a medication daily, regardless of symptoms, and using an inhaler when symptoms arise. As reported in The Journal of Allergy and Clinical Immunology, this study focused exclusively on African-American children, who have traditionally been underserved in research and have had worse asthma-related health outcomes than other children.
Peer-Led Classes Effective in Treating Substance Use Disorder, PTSD
A PCORI-funded project centered in a rural New Mexico area lacking mental health professionals examined whether using trained peers to lead group therapy classes for patients with substance use disorder or posttraumatic stress disorder (PTSD) could be an effective alternative to using health professionals with master’s degrees. As reported in the Community Mental Health Journal, the group who received classes led by trained peers had as much improvement as the group who received classes from the professionals
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Whicher D, Philbin S, Aronson N. An overview of the impact of rare disease characteristics on research methodology. Orphanet J Rare Dis. 2018 Jan 19;13(1):14. doi: 10.1186/s13023-017-0755-5. Review. PubMed PMID: 29351763.
Forsythe LP, Szydlowski V, Murad MH, Ip S, Wang Z, Elraiyah TA, Fleurence R, Hickam DH. A systematic review of approaches for engaging patients for research on rare diseases. J Gen Intern Med. 2014 Aug;29 Suppl 3:S788-800. DOI: 10.1007/s11606-014-2895-9. Review. PubMed PMID: 25047393; PubMed Central PMCID: PMC4124116.
Khodyakov D, Kinnett K, Grant S, Lucas A, Martin A, Denger B, Peay H, Coulter I, Fink A. Engaging Patients and Caregivers Managing Rare Diseases to Improve the Methods of Clinical Guideline Development: A Research Protocol. JMIR Res Protoc. 2017 Apr 28;6(4):e57. doi: 10.2196/resprot.6902. PubMed PMID: 28455279; PubMed Central PMCID: PMC5429434.