This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Depression Drug Offers Modest Outcomes Over Cognitive Therapy for Patients Undergoing Hemodialysis
Patients undergoing long-term treatment for kidney failure often also experience depression. In a PCORI-funded study, more patients reported modest improvements in their depressive symptoms with the drug sertraline than patients who received cognitive behavioral therapy, the study’s researchers report in the Annals of Internal Medicine. However, patients who opted for the daily medication experienced more adverse events, such as nausea and dizziness.
Engaging Parents in Hospital Rounds to Help Reduce Medical Errors
Despite ongoing efforts to improve care, medical errors—mistakes that may or may not harm patients—are a leading cause of death nationally. Improving communication in the hospital can help reduce errors. To that end, a PCORI-funded research team tested a program called I-PASS that includes parents as active participants in pediatric unit rounds at eight hospitals to see whether it would improve hospital safety. As The BMJ reports, the program reduced harmful medical errors—preventable adverse events—by 38 percent.
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Frank L, de Wit M, Kirwan JR, Guillemin F, Bartlett SJ. Author Response: Patient Engagement. Value Health. 2017 Dec;20(10):1433. doi:10.1016/j.jval.2017.10.010. PubMed PMID: 29241905.
Sheridan S, Schrandt S, Forsythe L, Hilliard TS, Paez KA; Advisory Panel on Patient Engagement (2013 inaugural panel). The PCORI Engagement Rubric: Promising Practices for Partnering in Research. Ann Fam Med. 2017 Mar;15(2):165-170. DOI: 10.1370/afm.2042. PubMed PMID: 28289118; PubMed Central PMCID: PMC5348236.