This collection of journal publications provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Direct Oral Anticoagulants versus Warfarin for Stroke Treatment
The PCORI-funded PROSPER study compared outcomes of older adults who have atrial fibrillation and have had a stroke. In a paper published in JAMA Neurology, the research team reports that patients who were prescribed direct oral anticoagulants when discharged from the hospital following a stroke had relatively better outcomes—including more days at home and fewer adverse events—than patients prescribed the blood thinner warfarin. This reinforces findings from prior research on the subject.
Nondrug Therapies for Treating Insomnia in Patients With Cancer
Thirty to 50 percent of patients with cancer experience insomnia, often caused by medications or anxiety about their diagnosis. This PCORI-funded Sloan Kettering Institute for Cancer Research-based project found that patients like these might see improvement in quality of sleep and quality of life through nondrug treatments like acupuncture and cognitive behavioral therapy (CBT). Researchers say in an article in the Journal of the National Cancer Institute that while both therapies seem to help, CBT was more effective.
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Forsythe LP, Carman KL, Szydlowski V, Fayish L, Davidson L, Hickam DH, Hall C, Bhat G, Neu D, Stewart L, Jalowsky M, Aronson N, Anyanwu CU. Patient Engagement In Research: Early Findings From The Patient-Centered Outcomes Research Institute. Health Aff (Millwood). 2019 Mar;38(3):359-367. doi: 10.1377/hlthaff.2018.05067. PubMed PMID: 30830822.