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WASHINGTON, DC—The Patient-Centered Outcomes Research Institute (PCORI) has opened the application periods for eight funding opportunities that offer up to $297.5 million in total funding. The latest PCORI Funding Announcements (PFAs) include up to $262 million for comparative clinical effectiveness research (CER) studies that help determine which health care options or approaches work best for patients and their caregivers given their particular circumstances.

These first funding opportunities of 2022 advance PCORI’s ambitious three-year funding commitment plan totaling $1.8 billion, which the PCORI Board of Governors approved last year.

“PCORI proudly continues its important and unique role as the nation’s leading public funder of patient-centered comparative clinical effectiveness research,” said PCORI Executive Director Nakela L. Cook, M.D., M.P.H. “In a world of seemingly endless health information sources, and misinformation about clinically effective interventions, sound data that can help people make sense of their many options in a complex health care environment has never been more important.”

The largest funding announcement, the Broad Pragmatic Studies PFA, seeks proposals for CER studies lasting up to five years with up to $5 million or up to $10 million in direct costs per study in four priority areas: addressing disparities; assessment of prevention, diagnosis, and treatment options; communication and dissemination research; and improving health care systems. PCORI offers up to $162 million through this PFA.

Three Targeted PFAs seek proposals for CER studies focused on brief interventions for adolescent alcohol use; prevention, early identification, and treatment of delirium in older adults; and interventions targeting mental health in individuals with intellectual and developmental disabilities. Collectively, PCORI offers up to $100 million through these three PFAs.

One additional PFA providing up to $12 million seeks proposals for studies on improving methods to conduct patient-centered CER to enhance the scientific rigor of this field of research.

In addition, three other funding announcements, together offering up to $23.5 million, seek proposals for projects to implement results of PCORI-funded research and advance approaches to effective shared decision making in practice settings. These PFAs aim to help useful research findings that have been shown to improve outcomes get taken up and used more widely and quickly in health care delivery.

The funding opportunities follow PCORI’s recent unveiling of its proposed Research Agenda to provide the framework for its future funding of CER and other research initiatives. PCORI invites public comment through January 31 on the proposed Research Agenda, which stems from the five National Priorities for Health adopted by PCORI’s Board of Governors in October 2021.

Details on these most recent funding announcements and all studies approved for funding are on PCORI’s website. To date, PCORI has invested about $3.3 billion to fund patient-centered CER and to support other projects designed to enhance CER methods and the infrastructure necessary to conduct CER rigorously and efficiently.


The Patient-Centered Outcomes Research Institute (PCORI) is an independent nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers and clinicians with the evidence-based information needed to make better-informed healthcare decisions. PCORI is committed to continually seeking input from a broad range of stakeholders to guide its work.

For Media Inquiries Only, Contact:

Christine Stencel

  • Associate Director of Media Relations

[email protected]

Sofia Kosmetatos

  • Senior Media Relations Specialist

[email protected]

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The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

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