The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved $97.9 million to fund 11 studies comparing different approaches to improving care for a range of health conditions that impose high burdens on patients, caregivers and the healthcare system.
The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved about $38 million to fund five studies comparing the effectiveness of different strategies for treating multiple sclerosis (MS).
Learn more about our work, the research we fund, and our programs and initiatives.
PCORI's Research Funding
Find out what type of research PCORI supports and what we have funded.
Research Done Differently
We're committed to a new approach to health research. Learn how it’s different.
Better Research Through Engagement
Find out what we mean by engagement, how PCORI engages patients and other healthcare stakeholders, and how we encourage others to do so.
Targeted Funding Announcements
Learn more about our research on specific, high-priority topics likely to have a substantial impact on practice and patient outcomes.
Pragmatic Clinical Studies Initiative
Learn more about this funding opportunity aimed at comparing outcomes of two or more interventions to healthcare issues faced by patients.
Dissemination & Implementation
Read how we’re speeding up the process of getting the word out on results from our funded projects.
PCORI’s initiative to evaluate all relevant completed studies on a question or topic to clarify what is known and what evidence gaps need to be filled.
PCORI’s Milestones at Age 6
An overview of our milestones since being created in the fall of 2010.
The PCORI Application Process
Learn how to apply for PCORI funding, with listings of applicant resources, frequently asked questions, and keys for success.
Become a PCORI Peer Reviewer
We encourage interested patients, caregivers, clinicians, researchers, and other healthcare stakeholders to sign on to become Peer Reviewers. We want to ensure that research studies funded by PCORI are held to the highest standards of scientific integrity and usefulness to stakeholders.
Help Wanted - PCORI Reviewers
We invite patients, scientists, and other healthcare stakeholders to help us review applications for funding.
Why Methods Matter
See how we are supporting development and use of best methods for patient-centered outcomes research.
PCORnet - the National Patient-Centered Clinical Research Network
Learn what networks are part of this coalition and how it will support clinical research.
PCORnet Demonstration Studies
Learn more about how PCORI-funded PCORnet demonstration studies are testing PCORnet's infrastructure and answering key research questions.
PCORnet’s First Observational Studies
Find out more about research to address questions on the treatment and prevention of obesity.
The PCORnet ADAPTABLE Aspirin Study
Read about this study that will help determine the best dose of aspirin to use to prevent heart attacks and strokes in people with heart disease.
Funded Research Snapshots
Read examples of our patient-centered comparative research in action.
PCORI maintains a robust portfolio of patient-centered outcomes research that addresses a variety of high-priority conditions and topics. Find summaries and entry points to explore our research in several of these areas.
Posted: September 30, 2014; Updated: June 16, 2017
This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
Featured Articles on Prostate Cancer
Men who were treated with either the latest forms of surgery or radiation therapy experienced greater rates of problems, either urinary, bowel or sexual, during the first several months afterward as compared to those who opted to wait and closely monitor their cancer. However, the outcomes among all groups were similar after two years, according to findings published in the Journal of the American Medical Association from a study led by Ronald Chen.
Surgery to treat prostate cancer, including robot-assisted procedures, was associated with greater rates of incontinence and sexual problems than either external beam radiation or watchful waiting even three years afterward. But surgery also resulted in fewer other urinary symptoms than active surveillance, according to findings published in the Journal of the American Medical Association from a study led by David Penson.
PCORI Awardees' Peer-Reviewed Publications
View a list of peer-reviewed publications resulting from studies fully or partially funded by PCORI. These publications have been identified based on funding acknowledgements in the articles and/or reports from principal investigators.
Recent Open-Access Articles
As part of their large study, David Nelson and colleagues conducted a systematic review of 42 published studies of new drugs for hepatitis C infections. As reported in the Annals of Internal Medicine, they found all the treatment regimens to be highly effective and well-tolerated in general. However, they saw some variation in outcomes linked to particular types of virus and patient characteristics, such as having other conditions like chronic kidney disease or HIV.
Including family members of hospitalized patients in the effort to report medical errors and adverse events increased the capture of such errors by 16 percent and capture of adverse events by 10 percent, according to findings in JAMA Pediatrics. The findings stem from a study led by Christopher Landrigan.
Posted: March 5, 2014; Updated: August 4, 2017