Highlights of PCORI-Funded Research Results
PCORI began funding research in 2012, and a growing number of the studies are now producing important results that are being published in peer-reviewed journals or presented at scientific meetings.
Explore Our Portfolio of Funded Projects
Find out about projects based on the health conditions they focus on, the state they are in, and if they have results.
Latest Results from PCORI-Funded Research
Matching Patients Seeking Mental Health Care with Therapists
Patients seeking mental health care who were matched with therapists who have a good track record of treating the patients' particular needs and concerns resulted in better outcomes, compared with non-matched patients, according to findings from a PCORI-funded study published in JAMA Psychiatry.
Treatment Duration for Newborn Infants Who Have Seizures
Reporting in JAMA Neurology, a PCORI-funded study found that after two years, newborns treated with antiseizure medication (ASM) prior to hospital discharge and those who continued ASM after hospital discharge did not differ significantly in their functional development and risk of epilepsy.
Outcomes of Patients with Multiple Sclerosis Taking Certain Drugs
Findings published in the Annals of Clinical and Translational Neurology from the PCORI-funded COMBAT-MS Study's COVID-19 research enhancement show that patients taking the drug rituximab were at increased risk of hospitalization but not ventilatory support or death from COVID‐19, compared to the general population.
Aspirin Dosing Study Outlines Long-Term Effectiveness, Benefits
Results from the PCORI-funded ADAPTABLE Study, appearing in the New England Journal of Medicine and presented at a national cardiology scientific meeting, indicate that lower- and higher-dose aspirin achieve similar protection and safety for people with heart disease.
Treating Back Pain Using a Stratified Risk Approach
New results appearing in EClinicalMedicine from a study that tested risk-stratified treatments for patients with acute back pain found that among patients at high risk, half developed chronic back pain regardless of type of care, while 20 percent of low-risk and 33 percent of medium-risk patients developed chronic low back pain.
Surgical Treatments for Cervical Spondylotic Myelopathy (CSM)
Reporting in JAMA, a PCORI-funded study on CSM found that patients whose treatment had a dorsal surgical approach experienced better physical function and were less likely to report using opioids for pain or needing ongoing physical therapy, compared with a ventral surgical approach.
A Risk-Based Approach for Triaging Breast Cancer Screenings
Findings from a PCORI-funded study, published in JAMA Network Open, suggest that a risk-based approach during periods of reduced capacity, such as the COVID-19 pandemic, could result in detecting the most cancers while performing the fewest examinations compared with a non-risk-based approach.
New Treatment for Chronic Hepatitis C Virus Offers Benefits
Reporting in Liver International, a PCORI-funded research team examined short- and long-term effects of the treatment and found that patients experienced improvements like less fatigue and better sleep quality three months after completing treatment, which held over 12 months.
Comparing Ways to Treat People with Obesity in Rural Areas
Recent results in JAMA from a PCORI-funded study, which compared three ways to treat obesity in rural populations, show that people averaged greater weight loss through in-person group sessions than in-person clinic and phone-based sessions.
