Final Research Report

View this project's final research report.

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.

Peer review identified the following strengths and limitations in the report:

  • The awardee addressed reviewers’ concerns about the generalizability of study results and the report’s inadequate emphasis on study population characteristics in the final report. Reviewers noted that the study population consisted of children considered low risk for reinfection or treatment failure, who only make up about 25-30 percent of all children requiring antibiotics for serious infections. The awardee responded that the study protocol and published papers clearly indicated that the children in this study were low risk.
  • The awardee addressed comments from the statistical reviewer by referring the reader to previously published papers that have details on study methods and analyses.
  • Responding to reviewer requests for more details on the methods for insuring consistency and limiting interrater variability, the awardee added language describing chart reviewers’ training. The awardee also noted that the team did not measure how often different raters disagreed in their reviews of medical charts.
  • The investigator did not respond to reviewers’ questioning of the conclusion that there were no differences in treatment failure on oral antibiotics between hospitals that had low versus high use of peripherally inserted central catheters. The lack of sample sizes for this comparison and the wide confidence intervals for the odds ratio did not provide sufficient evidence to warrant this conclusion.

Conflict of Interest Disclosures

Project Information

Ron Keren, MD, MPH
The Children's Hospital of Philadelphia
$1,415,713
10.25302/11.2018.CER.526
Comparative Effectiveness of Intravenous vs. Oral Antibiotic Therapy for Serious Bacterial Infections

Key Dates

December 2012
February 2018
2012
2018

Study Registration Information

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Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 4, 2022