Results Summary and Professional Abstract
Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.
The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.
Reviewers’ comments and the investigators changes in response included the following:
- In general, the reviewers found the report to be a comprehensive description of the patient-reported outcomes validation study.
- The reviewers questioned the limited use of crosswalks, which are tables describing equivalent and differing items within two sets of items such as outcome measures. The reviewers questioned why the investigator used so few crosswalks between existing disease-specific measures and the newly created disease-specific items for PROMIS measures. The investigator explained that such crosswalks were possible only with measures of the same constructs. The investigator also explained that the measures the study developed were not consistently of the same constructs, limiting the use of crosswalks.
- Some reviewers expressed concern that adding disease-specific items to the widely accepted PROMIS measures would dilute the value of generic measures that span disease and condition areas. The investigator responded by stating that it intended the new items to expand, not limit, the usability of PROMIS measures by including items that would speak to disease-specific experiences.
Conflict of Interest Disclosures
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