Final Research Report
View this project's final research report.
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Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also confirms that the research has followed PCORI’s Methodology Standards. During peer review, experts who were not members of the research team read a draft report of the research. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. Reviewers do not have conflicts of interest with the study.
The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve how the research team analyzed its results or reported its conclusions. Learn more about PCORI’s peer-review process here.
In response to peer review, the PI made changes including
- Adding details about the sensitivity analyses that the author conducted, as these were mentioned in the Methodology Standards checklist but initially not described in the text of the report.
- Addressing reviewer questions about whether the statistically significant difference found on the PedsQL (pediatric quality of life measure) was clinically meaningful. The researchers added cautions about interpreting the results from this measure because the measure was not originally designed to assess child quality of life following acute respiratory infection, and because the small differences between patients treated with narrow- and broad-spectrum antibiotics were unlikely to be clinically meaningful.
- Noting an additional limitation of the study: the analyses did not account for baseline PedsQL measures and any chronic conditions.
- Explaining that the sampling strategies were different for the patient-centered outcomes cohort and the clinician-centered outcomes cohort. This was because the researchers stratified the recruitment of patients for patient-centered outcomes cohort by diagnosis and antibiotic type, and oversampled certain strata to insure adequate numbers to conduct analyses. This was unnecessary for the inclusion of clinicians in the clinician-centered outcomes cohort.
Conflict of Interest Disclosures
- Has Results