Final Research Report

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Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments. 

Peer reviewers commented, and the researchers made changes or provided responses. The comments and responses included the following:

  • Reviewers commented on the presence of multiple differences among the three study sites that could have affected study outcomes, differences that went beyond the fact that one site offered home-based rehabilitation services and the two other sites offered facility-based rehabilitation services. The researchers added Table 1 to clarify the differences across the intervention sites and explained the reasons for some of the differences.
  • Among the differences across sites, reviewers noted differences in the average time between clinical events and the initiation of rehabilitation services, suggesting that the analyses control for these differences. The researchers clarified that the shorter time between the clinical event and rehab initiation is an important outcome of the study rather than a difference in the interventions. They also added a multivariable model, (Table 9, Model 3) that did control for number of days to enrollment.
  • Reviewers noted that patients dropping out of the study undermined the value of the longest follow-up interval, 6 months. The researchers acknowledged that this was a limitation of the study despite their best efforts to retain participants. However, the researchers also noted that since there were no differences in baseline characteristics between the participants who were and were not lost to follow up at 6 months, there was no reason to believe that patients who dropped out were either sicker or more functionally impaired than those who remained in the study.

Conflict of Interest Disclosures

Project Information

Mary Whooley, MD
University of California San Francisco
$1,932,960
10.25302/05.2020.IH.13046787
Improving Delivery of Patient-Centered Cardiac Rehabilitation

Key Dates

September 2013
April 2019
2013
2019

Study Registration Information

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Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
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Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Last updated: March 4, 2022