Final Research Report

View this project's final research report.

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.

Peer review identified the following strengths and limitations in the report:

  • The reviewers were impressed with the quality of the report and the interesting subject of this methods development study.
  • The reviewers questioned the 1:1 matching approach to create a dataset of matched patients with total knee replacement (TKR) and patients who chose medical therapy instead. The authors acknowledged that this matching approach could limit generalizability, as the medical therapy (non-TKR) patients were chosen to match the TKR patients, and not to provide a representative sample. But the authors noted that this approach reduces the effect of variables that influence choice of therapy and, independently, the outcome of therapy.

Conflict of Interest Disclosures

Project Information

Harry P. Selker, MD, MSPH
Tufts Medical Center
$1,123,588
10.25302/9.2019.ME.130602327
A Method for Patient-Centered Enrollment in Comparative Effectiveness Trials: Mathematical Equipoise

Key Dates

December 2013
July 2018
2013
2018

Study Registration Information

Tags

Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
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Last updated: March 4, 2022