Final Research Report

View this project's final research report.

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments. 

Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:

  • Because so many patients were lost to follow-up, the reviewers requested that the researchers reanalyze the data including all patients with an initial assessment, even if patients did not have outcome data. The researchers responded that they chose their mixed-model approach specifically to deal with the expected missing data. The researchers stated that they required only that a person have a baseline and one post-baseline assessment for inclusion in the analyzed sample; the researchers did not require complete data for inclusion. As reviewers requested, the researchers did run additional analyses on primary outcomes and any significant secondary outcomes including all people with baseline data, but they kept the original primary analyses, as well.
  • The reviewers asked the researchers to expand the discussion of limitations. The researchers added a limitation related to the large amount of missing outcome data. Researchers said that due to missing data, the sample they analyzed could have been systematically different from the original study sample. The investigators also stated that replication of the study results might be difficult because the study did not follow a framework for an intention-to-treat analysis because the analyzed sample did not include all the patients randomly assigned to the group receiving the intervention.
  • The reviewers also argued that randomizing patients before obtaining full informed consent is a study limitation. Randomizing before consent could preclude a true intention-to-treat analysis because some randomized patients might choose not to participate in the study, the reviewers said. The researchers explained that if they had randomized after initial data collection, they would have captured only those patients motivated to engage in transitional care. Therefore, researchers thought they would not get a truly representative sample of the population if they had randomized at this later stage.
  • The reviewers questioned the significance of evaluating joint intake versus individual intake appointments within the transitional care center training. The researchers noted that many of their stakeholders considered this question to be very important because joint intake procedures could speed access to services.

Conflict of Interest Disclosures

Project Information

Dawn I. Velligan, PhD
University of Texas Health Science Center at San Antonio
$1,350,565
10.25302/8.2019.IH.13046506
Improving Transitional Care Experience for Individuals with Serious Mental Illness

Key Dates

September 2013
April 2017
2013
2018

Study Registration Information

Tags

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Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Funding Opportunity Type
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Research Priority Area
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 4, 2022