Final Research Report

View this project's final research report.

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments. 

Peer reviewers commented, and the researchers made changes or provided responses. Those comments and responses included the following:

  • The reviewers questioned the adequacy of the multivariable models of the choice of breast cancer treatments, breast conserving surgery versus radiation therapy. The researchers acknowledged that there were some unmeasured factors, such as previous hormone use and availability of radiation oncology services, that could influence women’s decision making. They noted in their limitations that the study did not include these factors as potential confounders.
  • The reviewers expressed concern about the low rate of reporting of estrogen receptor (ER) status, 14 percent, in the data set, given the results showing the association of ER status with the occurrence of contralateral breast cancer. The reviewers noted the possibility that this association was invalid given the amount of missing data for ER status. They also noted the possibility of this association being invalid given the potential for a difference in the women for whom ER status was known and the women whose ER status was unknown. The researchers acknowledged that the lack of additional information on ER status limited the conclusions that could be made from these results. However, they also noted that although testing for ER status varied systematically based on the sophistication of specific clinics or regions, there was no reason to believe that the consequent systematic selection of patients for ER testing would bias the clinical characteristics of ER positive versus ER negative cases.

Conflict of Interest Disclosures

Project Information

Rinaa Punglia, MD, MPH
Dana-Farber Cancer Institute
$1,203,120
10.25302/1.2020.CE.12114173
Impact of Radiation Therapy on Breast Conservation in DCIS

Key Dates

May 2013
September 2018
2013
2018

Study Registration Information

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Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 4, 2022