Final Research Report

View this project's final research report.

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments. 

Peer reviewers commented, and the researchers made changes or provided responses. The comments and responses included the following:

  • The reviewers said the study should emphasize the lack of significant effects in the primary outcome measure before discussing any significant findings in secondary outcomes. The researchers updated the report to do so.
  • The reviewers noted that given the large number of secondary outcomes measured, positive results should be interpreted with caution. In particular, they expressed concern because the analyses for these outcomes were not adjusted for multiple comparisons. The researchers revised the report to highlight null results and introduce additional notes of caution.
  • The reviewers recommended including additional detail to help explain the meaningfulness of the results, beyond stating the statistical significance with a P value. The researchers added 95% confidence intervals for the key outcome estimates, providing more precision around the significance of the results. The researchers noted that many of their patient-reported scales did not have clinically relevant units that could be reported.
  • Some reviewers expressed concern that the study encouraged chronic care patients to curtail opioid use, which might not be clinically appropriate. The researchers responded that their intervention did not make clinical recommendations and did not aim to discourage opioid use. The researchers explained that instead they aimed to empower patients to communicate with providers and explore alternative ways to manage pain. The researchers said they used input from patient advisors in trying to develop a balanced curriculum for their intervention.

Conflict of Interest Disclosures

Project Information

Cynthia Campbell, PhD, MPH
Kaiser Foundation Research Institute
$1,975,913
10.25302/10.2019.IHS.131008734
Prescription Opioid Management in Chronic Pain Patients: A Patient-Centered Activation Intervention

Key Dates

July 2014
September 2018
2014
2018

Study Registration Information

Tags

Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Funding Opportunity Type
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Research Priority Area
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 4, 2022