Final Research Report

View this project's final research report.

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.

Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:

  • The reviewers asked for greater clarity on when participants were randomly assigned to the intervention versus control groups because in some places the report indicated that group allocation occurred prior to the baseline home visit. The researchers explained that the study’s statistician randomized assignments upon confirming each patient’s eligibility, and study staff and participants found out patients’ study group assignments at the baseline home visit after the baseline measures had been collected.
  • The reviewers then noted that out of the 186 individuals randomized to the intervention versus control groups before the baseline home visit, 120 completed the baseline visit. The reviewers recommended that the researchers conduct intent-to-treat analyses that included all 186 individuals, rather than only analyses on the 120 who completed baseline visits. The researchers added these analyses and presented a more in-depth series of tables and figures based on this reanalysis, which they said revealed no difference in treatment effect. At the reviewers’ recommendation, the researchers also added a comment about the large drop-out number in describing their study limitations.
  • The reviewers questioned the approaches taken to address missing data and asked the researchers to clarify their strategies and to include their sensitivity analyses in the report. The researchers revised the report to explain that they came to a belief that the missing data in their study were missing at random because there were no external occurrences that could have affected which data were missing and when. In addition, their sensitivity analyses tested whether the results for skin and soft tissue recurrence changed if the missing values were all set to yes or all set to no. The researchers presented these results, which demonstrated no significant changes in the results based on these analyses.

Conflict of Interest Disclosures

Project Information

Jonathan N. Tobin, PhD
Clinical Directors Network, Inc.
$2,667,028
10.25302/08.2020.CER.140210800
Patient-Centered CER of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence

Key Dates

September 2014
October 2019
2014
2019

Study Registration Information

Tags

Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 4, 2022