The Greater Plains Collaborative (GPC) is currently a network of leading medical centers across the central United States who are committed to a shared vision of improving healthcare delivery through ongoing learning, adoption of evidence-based practices, and active research dissemination.
The GPC is strongly committed to PCORnet and to providing the structure to develop and support diverse research with meaningful patient involvement. Current capabilities resulted in successfully funded projects as well as protocols under development: “Midwestern Collaborative for Treating Obesity in Rural Primary Care; “Identifying Breast Cancer Patients Receiving Autologous Fat Grafting”; “Comparative Effectiveness Study of Treatment of Sialorrhea in Patient with ALS”; “A Pragmatic Clinical Trial of Nighttime Dosing of Anti-Hypertensive Medications”; “Finding Fractures and Osteoporosis Using Native Data from Computed Tomography”; “Inter-Clinical Data Research Network Collaboration on Sickle Cell Disease” ; “Research Literacy: Empowering Patients as Research Team Members”; and a CDC diabetes proposal.
During Phase I, the GPC partners developed three cohort surveys (breast cancer, amyotrophic lateral sclerosis [ALS], and obesity), participated in task forces, and provided methodology expertise to ADAPTABLE: The Aspirin Study. The GPC has delivered required data dictionaries, established PopMedNet nodes, conducted tests queries with the PCORnet Coordinating Center, and fully instantiated enterprisewide PCORnet common data model tables at the majority of its sites. While based in our medical centers’ Clinical and Translational Science Awards and Institutes (CTSAs), the GPC’s incorporation of standardized cancer tumor registries at all its sites creates a unique resource for extending comparative effectiveness research (CER) in support of cancer centers. All GPC sites participated in the execution of an Institutional Review Board master reliance agreement as well as a data sharing agreement. GPC investigators participated with and engaged patients who attended our Learning Engagement Kickoff in August.
In Phase II, the GPC will offer broadened network leadership and productive partnerships across clinical data research networks and five patient-powered research networks. We will create enhanced data resources to support observational/interventional research by adding record linkage and duplication analysis capabilities with new data partners, and deploying free text note de-identification and processing to support advanced computable phenotyping at a vast scale across our data warehouses. We will establish new approaches to research opportunity assessment and integrated pilot programs with our CTSAs to develop proficient CER collaborators from every perspective. We will work with patients, entrepreneurial organizations, insurers, and private industry to position the GPC in broad service to advancing our nation’s health and will create a network that is responsive and ultimately sustainable for both external and internal research initiatives.
View more about this project on PCORnet.org.