Final Research Report
View this project's final research report.
Results of This Project
Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.
The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.
Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:
- The reviewers noted that there are medications often prescribed for patients with multiple sclerosis that could affect patient fatigue and thereby interact with the study treatments. The researchers acknowledged that other medications could affect the severity of patient fatigue but there were no changes in concomitant medications during the study period, so there would be no effect of changes from other medications on study results.
- The reviewers noted that patients ending medications at the beginning of their study participation might not have had sufficient time to wash out of those medications and asked the researchers to discuss how they accounted for these carry-over effects in their analyses. The researchers added information to the report about medication half-life and their reasoning for a two-week washout period. They explained that two weeks should have been enough time to wash out of the medications that participants were taking and that analyses looking for carry-over effects found none. The researchers concluded that variation in the washout period did not affect the results.
Conflict of Interest Disclosures
Patient / Caregiver Partners
Rebecca Gemignani; National MS Society
Other Stakeholder Partners
Jennifer Graves MD, PhD
^Bardia Nourbakhsh, MD, was affiliated with The Regents of the University of California when this project was initially awarded.
- Has Results
- Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them.
- Neurological Disorders
- Multiple Sclerosis
PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders.
- Individuals with Disabilities
- Treatment of Multiple Sclerosis
PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care.
- Drug Interventions
- Assessment of Prevention, Diagnosis, and Treatment Options
The state where the project originates, or where the primary institution or organization is located.