Adolescents and young adults (AYAs) with chronic conditions face numerous challenges, including their health maintenance. Demands of everyday self-management with a chronic medical condition are complicated by significant needs and experiences during this developmental period, when individuals are cultivating their identities and exploring personal and professional roles. In Tier I, we partnered with AYAs with a spinal cord injury and their caregivers to learn from their experiences after they were injured, including time spent in the hospital and during transitions from rehabilitation settings into community life with a new disability. Unique needs and circumstances for these young people call for specialized services, which can address the complex medical and psychosocial needs that accompany this type of injury at this time in a person’s life. Going forward, we are expanding our diagnostic focus to include stakeholders associated with a variety of chronic conditions in order to learn from the challenges and successes of existing models of health care for AYAs with a chronic disease or disability. With a broad community of stakeholders, our team will consider how services for AYAs with chronic conditions should be optimally tailored. Furthermore, we will facilitate discussions and collaborations among a range of stakeholders to identify and promote meaningful and sustainable practices for research and care. With an organized and responsive work plan, we will foster valuable partnerships and community infrastructure to conduct research with and for AYAs with chronic conditions.