The National Council of La Raza/California State University Long Beach (NCLR/CSULB) Center for Latino Community Health, Evaluation, and Leadership Training; the Long Beach Department of Health and Human Services; St. Mary’s Medical Center; and The Children’s Clinic are collaborating with Latino residents from downtown Long Beach to create a community-informed proposal to address pre-diabetes prevention, diagnosis, and treatment among low-income Latinos living with pre-diabetes and their families. Together, we will create a proposal to carry out community-led comparative effectiveness research. Diabetes is among the top five causes of death in Long Beach. Mostly impacting minority groups, the percentage of adults diagnosed with diabetes, sugar diabetes, or borderline/pre-diabetes in Long Beach ranges by ZIP code from 15 percent to 24 percent. The 90813 ZIP code has the highest rate, with 24.3 percent of the adult population receiving either a diabetes or pre-diabetes diagnosis. This ZIP code also has the highest rate of poverty, the highest rate of Latino ethnic population, and the lowest high school graduation rate in the city. Furthermore, the 90813 ZIP code has the lowest amount of open space per 1,000 residents, 0.26 acres. The concentrated impact of high poverty, high Latino ethnic population makeup, and high rates of diabetes/pre-diabetes diagnosis together with community member motivation to act on this disparity creates an opportunity to work within a specific geography for the development of a Latino-focused pre-diabetes collaborative effort.