Final Research Report
View this project's final research report.
Related Journal Citations
Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.
The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.
Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:
- The reviewers were generally laudatory in their comments about this study and the potential for the prediction modeling methods.
- The reviewers asked the researchers to explain their use of the term harm in relation to clinical prediction models, because harm in clinical research typically refers to adverse patient outcomes. The researchers defined harm as a negative result from their decision curve analyses, indicating that using the clinical prediction model to make treatment decisions had net harm rather than net benefit.
Conflict of Interest Disclosures
Patient / Caregiver Partners
- Bray Patrick-Lake MFS, Director, Stakeholder Engagement, CTTI; Director, Patient Engagement, Duke CTSA; Co-chair, NIH Advisory Committee, Director Working Group, Precision Medicine Initiative
Other Stakeholder Partners
- Gary S. Collins, PhD, Deputy Director, Centre for Statistics in Medicine, University of Oxford
- William H. Crown, PhD, Chief Scientific Officer, OptumLabs
- John K. Cuddeback, MD, PhD, Chief Medical Informatics Officer, Anceta Data Warehouse, AMGA
- Dana G. Safran, ScD, Senior Vice President, Performance Measurement and Improvement BCBS of MA
- John A. Spertus, MD, MPH, Chief Medical Officer/Director, Health Outcomes Sciences LLC; Cardiologist, Professor of Medicine, Mid Amerca Heart Institute, U of Missouri-Kansas City; Deputy Editor, Circ Cardiovasc Qual Outcomes
- James E. Udelson, MD, Chief of Cardiology, Tufts Medical Center; Professor of Medicine, Radiology, Tufts University School of Medicine
Study Registration Information
- Has Results