Final Research Report

View this project's final research report.

Journal Citations

Related Journal Citations

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments. 

Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:

  • The reviewers were generally laudatory in their comments about this study and the potential for the prediction modeling methods.
  • The reviewers asked the researchers to explain their use of the term harm in relation to clinical prediction models, because harm in clinical research typically refers to adverse patient outcomes. The researchers defined harm as a negative result from their decision curve analyses, indicating that using the clinical prediction model to make treatment decisions had net harm rather than net benefit.

Conflict of Interest Disclosures

Project Information

David M. Kent, MD, MS
Tufts Medical Center
$1,475,833
10.25302/09.2021.ME.160635555
How Well Do Clinical Prediction Models (CPMs) Validate? A Large-Scale Evaluation of Cardiovascular Clinical Prediction Models

Key Dates

December 2016
October 2022
2016
2021

Study Registration Information

Tags

Has Results
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Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
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Last updated: April 29, 2022