Results Summary

What was the research about?

Patients with cancer often have pain while in the hospital. Medicine can help ease pain but may have side effects. Adding treatments like acupuncture and pain counseling may reduce pain and improve quality of life. More hospitals might offer these treatments if more research shows they help patients.

In this study, the research team compared four ways to reduce pain among patients with cancer in the hospital:

  • Usual care alone. Patients received pain medicine based on their level of pain and how well their medicines have worked in the past.
  • Usual care plus acupuncture. Acupuncture involves inserting small needles into different parts of the body to treat health problems. Patients had at least one session in the hospital.
  • Usual care plus pain counseling. During counseling, patients discussed their attitude toward pain, pain treatments and side effects, coping skills, and ways to talk with healthcare providers, like doctors and nurses. Patients had at least one session in the hospital.
  • Usual care plus acupuncture and pain counseling. Patients had at least one session of acupuncture and one session of pain counseling.

What were the results?

About 41 percent of patients didn’t receive their assigned treatment, mostly due to patients’ choosing not to have it. As a result, the research team decided to analyze the data in two ways. The first way looked at all patients in the study. The second way looked just at patients who received their treatment.

Looking at all patients assigned to treatments, the four treatments didn’t differ in the decrease in pain.

Looking at patients who received treatments, patients who received acupuncture had larger decreases in pain than patients who received usual care alone. The decrease in pain didn’t differ for the other two treatments.

The four treatments didn’t differ in patients’ quality of life, emotional distress, or pain relief while in the hospital in any of the research team’s analyses.

Who was in the study?

The study included 447 adults with cancer who received care at one of two hospitals in California. Among patients, 53 percent were White, 25 percent were Latino, 10 percent were Asian, 7 percent were Black, and 6 percent identified as another race or ethnicity. The average age was 59, 50 percent were men, and 78 percent had early-stage cancer.

What did the research team do?

The research team assigned patients by chance to one of the four treatment approaches. At the start of the study and every day for up to four days during the hospital stay, the team surveyed patients on how they would rate their pain level, quality of life, emotional distress, and pain relief.

Patients, doctors, and administrators helped design the study.

What were the limits of the study?

Results may have differed if more patients had received their treatment.

Future research could continue to look at ways to help reduce pain for patients with cancer in the hospital.

How can people use the results?

Hospitals can use the results when considering ways to manage pain for patients with cancer.

Final Research Report

This project's final research report is expected to be available by March 2024.

Peer-Review Summary

The Peer-Review Summary for this project will be posted here soon.

Conflict of Interest Disclosures

Project Information

Maria Chao, DrPH, MPA
University of California, San Francisco
Nonpharmacologic Approaches to Relieve Pain and Symptom Distress among Diverse Hospitalized Cancer Patients

Key Dates

August 2017
December 2022

Study Registration Information


Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: June 29, 2023