Skip to main content
Patient-Centered Outcomes Research Institute
Patient-Centered Outcomes Research Institute
  • Blog
  • Newsroom
  • Find It Fast
  • Help Center
  • Subscribe
  • Careers
  • Contact Us

PCORI

Patient-Centered Outcomes Research Institute

Search form

  • About Us
    Close mega-menu

    About Us

    • Our Programs
    • Governance
    • Financials and Reports
    • Procurement Opportunities
    • Our Staff
    • Our Vision & Mission
    • Contact Us

    Fact Sheets: Learn More About PCORI

    Download fact sheets about out work, the research we fund, and our programs and initiatives.

    Find It Fast

    Browse through an alphabetical list of frequently accessed and searched terms for information and resources.

    Subscribe to PCORI Email Alerts

    Sign up for weekly emails to stay current on the latest results of our funded projects, and more.

  • Research & Results
    Close mega-menu

    Research & Results

    • Explore Our Portfolio
    • Research Fundamentals
    • Research Results Highlights
    • Putting Evidence to Work
    • Peer Review
    • Evidence Synthesis
    • About Our Research

    Evidence Updates from PCORI-Funded Studies

    These updates capture highlights of findings from systematic reviews and our funded research studies.

    Journal Articles About Our Funded Research

    Browse through a collection of journal publications that provides insights into PCORI-funded work.

    Explore Our Portfolio of Funded Projects

    Find out about projects based on the health conditions they focus on, the state they are in, and if they have results.

  • Topics
    Close mega-menu

    Topics

    • Addressing Disparities
    • Arthritis
    • Asthma
    • Cancer
    • Cardiovascular Disease
    • Children's Health
    • Community Health Workers
    • COVID-19
    • Dementia and Cognitive Impairment
    • Diabetes
    • Kidney Disease
    • Medicaid
    • Men's Health
    • Mental and Behavioral Health
    • Minority Mental Health
    • Multiple Chronic Conditions
    • Multiple Sclerosis
    • Obesity
    • Older Adults' Health
    • Pain Care and Opioids
    • Rare Diseases
    • Rural Health
    • Shared Decision Making
    • Telehealth
    • Transitional Care
    • Veterans Health
    • Women's Health

    Featured Topic: Women's Health

    Learn more about the projects we support on conditions that specifically or more often affect women.

  • Engagement
    Close mega-menu

    Engagement

    • The Value of Engagement
    • Engagement in Health Research Literature Explorer
    • Influencing the Culture of Research
    • Engagement Awards
    • Engagement Resources
    • Engage with Us

    Engagement Tools and Resources for Research

    This searchable peer-to-peer repository includes resources that can inform future work in patient-centered outcomes research.

    Explore Engagement in Health Literature

    This tool enables searching for published articles about engagement in health research.

    Research Fundamentals: A New On-Demand Training

    It enables those new to health research or patient-centered research to learn more about the research process.

  • Funding Opportunities
    Close mega-menu

    Funding Opportunities

    • What & Who We Fund
    • What You Need to Know to Apply
    • Applicant Training
    • Merit Review
    • Awardee Resources
    • Help Center

    PCORI Funding Opportunities

    View and learn about the newly opened funding announcements and the upcoming PFAs in 2021.

    Tips for Submitting a Responsive LOI

    Find out what PCORI looks for in a letter of intent (LOI) along with other helpful tips.

    PCORI Awardee Resources

    These resources can help awardees in complying with the terms and conditions of their contract.

  • Meetings & Events
    Close mega-menu

    Meetings & Events

    • Upcoming
    • Past Events

    PCORI Webinar: February 2, 2pm ET

    Hear from PCORI leaders about ways to get involved in PCOR, improvements to our funding opportunities, and more. Register

    Confronting COVID-19: A Webinar Series

    Learn more about the series and access recordings and summary reports of all six sessions.

    2020 PCORI Annual Meeting

    Watch recordings of all sessions, and view titles and descriptions of the posters presented at the virtual meeting.

You are here

  • Research & Results
  • Explore Our Portfolio
  • Comparing Strategies for Health Clini...

Comparing Strategies for Health Clinics to Increase HPV Vaccinations in Youth

Sign Up for Updates to This Study  

Project Summary  

PCORI has identified the need for large studies that look at real-life questions facing diverse patients, caregivers, and clinicians. In 2014, PCORI launched the Pragmatic Clinical Studies initiative to support large-scale comparative effectiveness studies focusing on everyday care for a wide range of patients. The Pragmatic Clinical Studies initiative funded this research project.

This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.

What is the research about?

Human papillomavirus, or HPV, is a sexually transmitted infection that can cause cancer or other health problems in men and women. An HPV vaccine for youth between the ages of 11 and 26 can protect them from HPV infection.

In this study, the research team is comparing three ways to increase the number of youth who get the HPV vaccine. One way is to send reminders to parents to have their child vaccinated. Another way is for clinics to provide specialized training for clinicians, such as doctors and nurses, and staff to make sure that the vaccine is offered to all eligible youth. The third way is to both send parent reminders and provide training for clinicians and health clinic staff.

Who can this research help?

Information from this study can help health clinics plan ways to increase use of the HPV vaccine among youth.

What is the research team doing?

The research team is working with seven Northeast Valley Health Corporation, or NEVHC, clinics in Los Angeles County to enroll 17,000 youth between the ages of 11 and 17 in the study. The clinics serve families with low incomes who have Medicaid or no insurance and speak mainly Spanish. The team is assigning the seven NEVHC clinics to one of three groups by chance.

In the first group, parents get a text message or mailed reminder to have their child vaccinated. In the second group, the research team trains clinicians and health clinic staff to make changes to clinic routines to ensure that the clinic always identifies youth who are eligible for the vaccine. The trainings also teach clinicians how to discuss the vaccine with parents and youth. In the third group, parents get a reminder to have their child vaccinated and researchers provide the same training for clinicians and staff.

The research team is looking at the health records of each child in the study to find out if the number of youth who have received the HPV vaccine increases over time. Researchers are also comparing how likely youth in each group are to be vaccinated.

Parents of youth who are patients at a NEVHC clinic; NEVHC clinicians, leaders, and staff; and people who work for community organizations that care about HPV vaccination are working with the research team to plan and conduct the study.

Research methods at a glance

Design Elements Description
Design Cluster randomized controlled trial using a stepped wedge factorial design
Population Youth ages 11–17 who have had at least 1 appointment in the last 2 years at 1 of the 7 NEVHC clinics participating in the study
Interventions/
Comparators
  • Parent reminders via letter or text message
  • Workflow changes; training, review, and feedback for clinicians and health clinic staff
  • Combination of parent reminders and health clinic training
Outcomes Primary: HPV vaccine series completed (based on electronic health record data)
Timeframe 1-year follow-up for study outcome

Project Details

Principal Investigator
Roshan Bastani, PhD
Project Status
In progress; Recruiting
Project Title
Comparative Effectiveness of System Interventions to Increase HPV Vaccine Receipt in Federally Qualified Health Centers
Board Approval Date
November 2017
Project End Date
May 2024
Organization
UCLA School of Public Health
Year Awarded
2017
State
California
Project Type
Research Project
Health Conditions  
Cancer
Cervical Cancer
Anal Cancer
Infectious Diseases
HPV and other Sexually Transmitted Infections
Rare Diseases
Intervention Strategies
Drug Interventions
Care Coordination
Other Health Services Interventions
Policy Interventions
Technology Interventions
Training and Education Interventions
Populations
Children -- 18 and under
Low Income
Racial/Ethnic Minorities
Women
Funding Announcement
Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes
Project Budget
$6,476,904
Study Registration Information
HSRP20184426
NCT03726151
Page Last Updated: 
September 28, 2020

Research & Results

  • Explore Our Portfolio
  • Research Fundamentals
  • Research Results Highlights
  • Putting Evidence to Work
  • Peer Review
  • Evidence Synthesis
  • About Our Research

About Us

  • Our Programs
  • Governance
  • Financials and Reports
  • Procurement Opportunities
  • Our Staff
  • Our Vision & Mission
  • Contact Us

Research & Results

  • Explore Our Portfolio
  • Research Fundamentals
  • Research Results Highlights
  • Putting Evidence to Work
  • Peer Review
  • Evidence Synthesis
  • About Our Research

Engagement

  • The Value of Engagement
  • Engagement in Health Research Literature Explorer
  • Influencing the Culture of Research
  • Engagement Awards
  • Engagement Resources
  • Engage with Us

Funding Opportunities

  • What & Who We Fund
  • What You Need to Know to Apply
  • Applicant Training
  • Merit Review
  • Awardee Resources
  • Help Center

Meetings & Events

February 2
PCORI 2021 and Beyond: Opportunities for Funding and Involvement in Patient-Centered Research
February 9
Board of Governors Meeting: February 9, 2021
February 11
Advisory Panel on Patient Engagement Winter 2021 Meeting

PCORI

Footer contact address

Patient-Centered Outcomes
Research Institute

1828 L Street, NW, Suite 900
Washington, DC 20036
Phone: (202) 827-7700 | Fax: (202) 355-9558
[email protected]

Subscribe to Newsletter

Twitter Facebook LinkedIn Vimeo

© 2011-2021 Patient-Centered Outcomes Research Institute. All Rights Reserved.

Privacy Policy | Terms of Use | Trademark Usage Guidelines | Credits | Help Center