Pilot Evidence Maps: Treatments for Fatigue in Multiple Sclerosis

A broad range of fatigue interventions for multiple sclerosis (MS) exists, including drugs, exercise, cognitive behavioral therapy, self-management strategies, and non-invasive brain stimulation. However, important questions remain regarding efficacy. The development of these evidence maps involved a systematic identification of relevant research studies of fatigue interventions in MS, along with data extraction, meta-analyses, and strength of evidence ratings.

These maps were created, in part, to help patients and those who care for them make informed decisions for a condition with multiple interventions available that typically may be selected based on individual preference or individual characteristics. The maps were primarily developed as pilots, to explore various methodologic issues encountered in this emerging form of evidence synthesis. Learn more about the evidence maps.

Evidence Maps and Evidence Visualizations

• Overview of All Study Designs for Multiple Sclerosis Fatigue Interventions
• Benefits and Harms of Multiple Sclerosis Fatigue Interventions
• Head-to-Head Comparisons of Frequently Used MS Fatigue Interventions