Project Summary

This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.

What is the research about?

When new clinical practice guidelines come out, it can be hard for doctors to change their practices. For example, guidelines now recommend that doctors use the test for human papilloma virus, or HPV, as the primary test to screen for cervical cancer, either alone or with the Pap test, for many women. But despite this guidance, doctors don’t always use the HPV test.

In this study, the research team is comparing two ways the Kaiser Permanente Southern California healthcare system, or KPSC, is using to try to increase doctors’ use of primary HPV screening. The first way is called a guided local-tailored approach. In this approach, clinics create a local project team that identifies barriers to doctors’ use of primary HPV screening. Then the team selects and applies strategies from an existing list to address those barriers. The second way is called a hybrid usual care approach. This approach involves standard education from KPSC followed by the clinic’s usual process for adopting new guidelines.

Who can this research help?

Results may help healthcare systems when considering ways to change care to reflect new guidelines or evidence.

What is the research team doing?

The research team is assigning 12 KPSC clinics by chance to either the guided local-tailored or hybrid usual care approach. The team is looking at health records for women ages 30–65 to see how often doctors order cervical cancer screening with primary HPV testing. Also, the team is asking doctors, nurses, and patients about their experiences switching to primary HPV testing.

Patients and providers are helping to choose study outcomes and design ways to collect data.

Research methods at a glance

Design Elements Description
Population 12 KPSC medical centers with 1,400 providers and 10,000 patients
  • Guided local-tailored approach
  • Hybrid usual care approach

Primary: provider-level uptake of primary HPV screening

Secondary: patient and provider knowledge of HPV test, patient and provider satisfaction with transition to primary HPV testing for routine cervical cancer screening, patient emotional reaction to HPV test and positive HPV test results, provider delivery of education, provider resistance to the new screening test

Timeframe 2-month follow-up for primary outcome

Project Information

Chun Chao, PhD, MS
Kaiser Foundation Research Institute, a Division of Kaiser Foundation Hospitals
Comparing Strategies for Implementing Primary HPV Testing for Routine Cervical Cancer Screening

Key Dates

November 2018
June 2024

Study Registration Information


Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 14, 2024