Final Research Report

View this project's final research report.

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Related PCORI-Funded Research Project

Examining Health Outcomes for People Who Are Transgender

Peer-Review Summary

Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.

The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments. 

Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:

  • A reviewer expressed concern that this project did not seem to formally engage with stakeholders, including transgender women. The researchers explained that this project is a relatively modest extension of the Examining Health Outcomes for People Who Are Transgender research study, which was driven by stakeholder input. The researchers felt that the data analysis undertaken for this report did not require a separate stakeholder engagement component. Instead, they discussed the analysis plans for this project with the advisory group for the original research study, which includes four transgender women.
  • A reviewer noted that there are very few studies that examine the effects of hormone therapy on health in the transgender or gender non-conforming communities and said the data in this report could be presented in ways that would be clearer to such patients. The researchers agreed about the dearth of such studies and noted that an advantage of the original research study is that it allows for additional studies to address multiple research questions. While this report was written for a scientific audience, the researchers said they will begin to disseminate their findings to the broader stakeholder community using a different type of communication.

Conflict of Interest Disclosures

Project Information

Michael Goodman, MD, MPH
Emory University
$817,383
10.25302/05.2021.AD.SS4532
Acute Thrombotic Events Following Feminizing Hormone Therapy

Key Dates

December 2022
2018
2021

Tags

Has Results
Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Research Priority Area
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 4, 2022