Pregnant women facing housing insecurity are among the most vulnerable populations served by the University of Arkansas for Medical Sciences (UAMS) Medical Center. In an effort to meet the needs of these mothers and their infants, a Homeless Infant Taskforce was convened in early 2017 to begin identifying the needs of the women and how to address those needs. The “Supporting Families in Crisis: Through Partnerships, Engagement & Research Conference” will provide an opportunity to build additional partnerships and collaborations within the community and to develop a research agenda to address the needs of the population. The aims of the conference are to facilitate an inclusive dialogue with patients, caregivers, providers, faith leaders, researchers, and other stakeholders to set and address research priorities to support the health and well-being of pregnant women and infants facing housing insecurity; and build the capacity of patients, caregivers, providers, faith leaders, researchers, and other stakeholders to conduct engaged research/patient-centered outcomes research (PCOR) and facilitate partnerships. To aid in the success of this project, UAMS and the Arkansas FAITH Network will be partnering with a variety of organizations including healthcare organizations, social service agencies, city government officials, faith-based groups/places of worship, and other nonprofit and for-profit entities.