Project Summary
Background and Objectives : Childhood obsessive-compulsive disorder (OCD) is a debilitating condition that interferes with educational, social, and emotional development. There has been considerable effort to develop empirically-supported treatments including various types of cognitive behavioral therapy (CBT). CBT is the first line treatment for youth with obsessive-compulsive disorders and is among the top preferences for treatment among family and patient stakeholders. Research to date has evaluated a number of CBT variants and add-ons using heterogeneous groups of patients but has yet to synthesize this evidence to help families and clinicians decide among them.
The goal of this project is to lay the foundation for a successful individual participant data meta-analysis (IPD-MA) collaborative. By the end of the project, consensus will be built among stakeholders and there will be support from the primary investigators of the core clinical trials and from key stakeholders in the field. Documents developed by working groups that will form the foundation of the collaborative.
Activities: A core guidance team will be created to focus on personalized outreach to key stakeholders and primary investigators coupled with working groups, and symposium/workshop presentations at prominent professional conferences (53rd Annual Convention of the Association for Behavioral and Cognitive Therapies and 27th Annual OCD Conference). Multiple personalized contacts with the community will generate excitement and develop the necessary collaboration to build the IPD-MA trial list collaborative than a single meeting or conference. The core guidance team will oversee three working groups focused on ethics, by-laws, and governance; scientific guidance, and data curation and analysis. Stakeholders will be invited to serve on the working groups and to attend workshops at two conferences frequented by pediatric OCD patients, clinicians, and researchers.
Outcomes and Outputs: The project will result in letters of support from principal investigators of the core trials in pediatric OCD and documents detailing policies, procedures, and plans developed by each of the working groups. These summary documents will form the foundation for a successful clinical trial collaborative.