PCORI has identified treatment for opioid use disorder as an important research topic. Patients, clinicians, and others want to learn: Can counseling, support groups, and similar programs help patients who are getting medicine-based treatment for opioid use disorder? To help answer this question, PCORI launched an initiative in 2018 on Psychosocial Interventions with Office-Based Opioid Treatment (OBOT) for Opioid Use Disorder. The initiative funded this research project and others.
COVID-19-Related Project Enhancement
COVID-19 has disrupted healthcare delivery and strained social networks, making it harder for patients with opioid use disorder (OUD) to stay in treatment and for their family members to support them. The original study leverages the family to prevent treatment interruptions by testing an in-person group for support persons called INSPIRE (Integrating Support Persons In Recovery).
The enhancement study will adapt INSPIRE to videoconference (eINSPIRE) with feedback from patients, support persons, and staff. Then, the study will pilot test eINSPIRE with support persons. Patients receiving buprenorphine will be eligible to nominate their support person for the study. The enhancement addresses the evidence gap regarding effectiveness of telehealth groups comprising family members for increasing patient OUD treatment retention.
Enhancement Award Amount: $497,054
This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.
What is the research about?
Opioid use disorder, or OUD, happens when people misuse, become addicted to, or take too many opioids at once. Doctors may use medicine to treat OUD. But many people stop taking their medicine, which increases their risk of using opioids again or taking too many opioids at once. Involving friends and family may help people stay on treatment for OUD.
In this study, the research team is testing a counseling program for people who support patients with OUD, including family members, spouses, and friends. The program is called Integrating Support Persons Into Recovery, or INSPIRE. INSPIRE draws from the Community Reinforcement and Family Training, or CRAFT, approach and teaches support people effective ways to help a person with OUD change their behavior. It also teaches ways for them to feel better themselves. The team wants to know if INSPIRE helps patients stay on OUD treatment and if it improves health outcomes for patients and their support people.
Who can this research help?
Results may help clinic leaders considering ways to help people with OUD and people who support them.
What is the research team doing?
The research team is recruiting 500 pairs of adults who are starting treatment for OUD and their support people. Patients are receiving treatment from 17 community health clinics in California.
The team is assigning the support people to receive either INSPIRE or the usual services available at clinics. INSPIRE consists of ten 90-minute in-person group sessions, led by two facilitators. The research team is interviewing patients and support people at the start of the study and again 3 and 12 months later. The team wants to see if INSPIRE helps patients keep using medicine to treat OUD and stop using opioids. In addition, the team is looking to see if INSPIRE improves depression and anxiety for patients and support people. Finally, the team wants to know if INSPIRE works better for some people than others, such as when a support person is a family member, spouse, or friend.
Patients, support people, clinic staff, psychologists, psychiatrists, and health insurers are helping to plan and conduct the study.
Research methods at a glance
Other Clinical Interventions
Other Health Services Interventions
Training and Education Interventions
Psychosocial Interventions with Office-Based Opioid Treatment for Opioid Use Disorder