Final Research Report
View this project's final research report.
Related Journal Citations
Peer review of PCORI-funded research helps make sure the report presents complete, balanced, and useful information about the research. It also assesses how the project addressed PCORI’s Methodology Standards. During peer review, experts read a draft report of the research and provide comments about the report. These experts may include a scientist focused on the research topic, a specialist in research methods, a patient or caregiver, and a healthcare professional. These reviewers cannot have conflicts of interest with the study.
The peer reviewers point out where the draft report may need revision. For example, they may suggest ways to improve descriptions of the conduct of the study or to clarify the connection between results and conclusions. Sometimes, awardees revise their draft reports twice or more to address all of the reviewers’ comments.
Peer reviewers commented and the researchers made changes or provided responses. Those comments and responses included the following:
- Reviewers noted that the methods developed in this study to create personalized treatment recommendations (PTR) did not adequately account for unmeasured confounding and patient treatment choice based on the expected gains for each patient. They recommended that the researchers create a conceptual model for their study and link back to it throughout the report. The researchers explained that their project assumes there is no unmeasured confounder, and that that this study was not designed to consider unmeasured confounders, so the reviewers’ suggestions were beyond the scope of this study. Rather than preparing a conceptual model, the researchers referred the reviewers to their potential outcome notation, Y(t), which is used throughout the report.
- The reviewers asked the researchers to explain their purpose in adding data across multiple data sources, commenting that multiple data sources would not solve the problem of estimating treatment outcomes in observational data. The researchers explained that combining multiple data sources improved the generalizability and stability of their PTR model.
Conflict of Interest Disclosures
Study Registration Information
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