Project Summary

This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.

What is the research about?

Black women tend to have higher-risk endometrial cancer, or EC, than White women. Black women are also less likely to survive EC. Treatment for high-risk EC may include chemotherapy, radiation, or immunotherapy. But without social support, some patients may delay or stop treatment sooner than doctors recommend.

In this study, the research team is comparing three ways to help Black women complete treatment for EC and decrease social isolation during treatment:

  • One-on-one peer support. A trained peer mentor who is a Black EC survivor holds 45-minute phone or video calls with each patient. Calls occur before, during, or shortly after a treatment visit. Peer mentors provide social support and tailor the discussion to meet the patient’s needs.
  • Group support. Patients attend weekly 60-minute group meetings with up to seven patients. A peer mentor who is a Black EC survivor leads the group, with discussion on topics such as treatment side effects, mental health, and nutrition. Group meetings also include discussions with experts on these and other topics.
  • Enhanced usual care. Patients receive materials with information on EC treatment and tips for managing side effects, mental health, and nutrition. The materials are written by Black EC survivors.

Who can this research help?

Results may help clinics when considering ways to offer social support for Black women receiving treatment for EC.

What is the research team doing?

The research team is enrolling 252 Black women with high-risk EC from nine health centers in the United States. Women in the study have a documented doctor’s recommendation to receive treatment with radiation, chemotherapy, and/or immunotherapy. The team is assigning women by chance to receive one-on-one peer support, group support, or enhanced usual care.

The research team is reviewing data from medical records to see if women finish treatment. The team is also surveying women at the start of the study and again one, three, and six months later. Surveys ask about social isolation and other aspects of quality of life. Also, the team is interviewing 15 women from each of the three groups at the start of the study and again six months later to learn about the support patients received and how well support strategies worked for patients. The team is also interviewing doctors, nurses, cancer center senior staff, and peer supporters about what they would need to offer peer support at more treatment centers.

Black women with EC are helping to design and conduct the study.

Research methods at a glance

Design Element Description
Design Pragmatic randomized controlled trial
Population 252 Black women with high-risk EC
  • One-on-one peer support
  • Group support
  • Enhanced usual care

Primary: treatment completion

Secondary: patient-reported social isolation

Timeframe 6-month follow-up for primary outcome

Project Information

Kemi Doll, MD, MS
University of Washington
Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence -- The SISTER Study

Key Dates

November 2020
April 2026

Study Registration Information


Award Type
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Last updated: March 14, 2024