Cardiovascular disease, including high blood pressure and stroke, has a disparate impact on African Americans. Conversely, this community has not been fully engaged to the degree desired in research ideation, implementation, and dissemination. Engaging diverse stakeholders that are traditionally not a part of PCOR requires building partnerships with a diverse group of organizations and institutions that have credibility and a cultural connection with racial and ethnic communities. For African-American communities in the southeast United States, this includes Historically Black Colleges and Universities (HBCU) and their community partners. The project team seeks to explore the role of HBCUs and partnered stakeholders in developing a culturally responsive framework for cardiovascular research and patient engagement in the southeast region of the United States.