This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.
What is the research about?
Each day in the United States, more than 50,000 patients receive general anesthesia for surgery. With general anesthesia, doctors give patients medicines to bring on a sleep-like state and keep patients from feeling pain during surgery.
Doctors use two main types of general anesthesia. The first type is total intravenous anesthesia, or TIVA. Doctors give TIVA through a vein. The second type is inhaled volatile anesthesia, or INVA. Patients breathe INVA in through a breathing tube.
TIVA and INVA are safe and effective but may have different benefits and harms. For example, some patients report feeling refreshed after surgery, while others report feeling groggy or ill. But questions remain about how each type of medicine affects recovery from surgery.
In this study, the research team is looking at how well patients receiving TIVA recover from surgery compared to patients receiving INVA.
Who can this research help?
Results may help patients and their doctors when considering types of general anesthesia for surgery.
What is the research team doing?
The research team is enrolling 12,500 adults receiving surgery at one of 20 hospitals across the United States. The team is assigning patients by chance to receive either TIVA or INVA.
The day after surgery and again one week and one month later, the research team is surveying patients about:
- The quality of their recovery
- Signs or symptoms of waking up during surgery
- Their ability to do daily activities
- Social support
- Delirium, or confused thinking and lack of awareness of one’s surroundings
- Quality of life
Patients who have had surgery are helping to plan and conduct the study.
Research methods at a glance
|Design||Randomized controlled trial|
|Population||12,500 adults undergoing scheduled noncardiac surgery expected to last more than 60 minutes and requiring general anesthesia|
Primary: quality of recovery, signs or symptoms of waking up during surgery
Secondary: physical independence, pain, social support, delirium, anxiety, depression, quality of life
|Timeframe||1-month follow-up for primary outcomes|