Neurological Disorders
Listed as a PCORI Priority in a Pragmatic Clinical Studies Funding Announcement
Insomnia: Compare the benefits and harms of pharmacologic, psychological, or combination treatments for treating different types of insomnia (sleep onset vs. sleep maintenance insomnia) on sleep and patient-centered outcomes including next-day function, mood, and quality of life.
(Listed as a PCORI Priority in a Pragmatic Clinical Studies Funding Announcement)
Approved for a Targeted Funding Announcement
Treatment of Multiple Sclerosis: What are the comparative benefits and harms of different disease-modifying therapies (DMTs) or therapeutic strategies in patients with relapsing, remitting multiple sclerosis on symptoms, functioning, quality of life, disease activity, and disease progression?
Stakeholder Workgroup (April 2015)
View the funding announcement
(Approved for a Targeted Funding Announcement)
Treatment of Multiple Sclerosis: What are the comparative benefits and harms of different approaches, other than DMTs, for ameliorating important symptoms in people with multiple sclerosis?
Stakeholder Workgroup (April 2015)
(Approved for a Targeted Funding Announcement)
Treatment of Multiple Sclerosis: What is the comparative effectiveness of tele-rehabilitation versus conventional direct care interventions for improving outcomes in people with multiple sclerosis, such as functional status, fatigue, and quality of life?
Stakeholder Workgroup (April 2015)
(Approved for a Targeted Funding Announcement)
Reviewed by Advisory Panels
Cognitive Impairment: Compare the effectiveness of pharmacologic and nonpharmacologic treatments (e.g., social/family support) in managing behavioral disorders for populations likely to experience disparities (i.e., racial/ethnic minorities, rural populations, low socioeconomic status populations) with Alzheimer’s disease and other dementias in home and institutional settings.
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(Reviewed by Advisory Panels)
Dementia: What is the comparative effectiveness of multicomponent management interventions for community-dwelling individuals with dementia in reducing caregiver burden and improving patient health-related quality of life?
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(Reviewed by Advisory Panels)
No Longer Under Active Consideration
Migraine: Compare pharmacologic and non-pharmacologic strategies to prevent the transition from episodic to chronic migraine.
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(Listed as a PCORI Priority in a Pragmatic Clinical Studies Funding Announcement/No Longer Under Active Consideration)
Migraine: Compare pharmacologic and non-pharmacologic strategies for treating individual headache episodes on the incidence of medication-overuse headache in patients with high-frequency episodic or chronic migraine.
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(Listed as a PCORI Priority in a Pragmatic Clinical Studies Funding Announcement/No Longer Under Active Consideration)
Multiple Sclerosis: Compare management options for modifying disease progression. These might include FDA-approved disease-modifying agents; behavioral interventions, including exercise and physical therapy; and complementary medicine alternatives.
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(Listed as a PCORI Priority in a Pragmatic Clinical Studies Funding Announcement/No Longer Under Active Consideration)
Cognitive Impairment: Compare the effectiveness of functional imaging tests for the evaluation of neurocognitive decline.
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(Reviewed by Advisory Panels/No Longer Under Active Consideration)
Cognitive Impairment: Comparative effectiveness of strategies for detecting mild cognitive impairment (MCI).
View the topic brief
(Reviewed by Advisory Panels/No Longer Under Active Consideration)
Epilepsy: Comparative effectiveness of treatment options for epilepsy in adults.
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(Reviewed by Advisory Panels/No Longer Under Active Consideration)
Sleep Disorders: Compare the effectiveness of clinical interventions to reduce sleep disorder disparities among racial/ethnic minorities.
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(Reviewed by Advisory Panels/No Longer Under Active Consideration)
Posted: October 26, 2015; Updated: December 12, 2017
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