This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Key Lifestyle Changes Can Help Patients with Obesity Lose More Weight, Keep It Off Longer, Study Finds
Reporting in the New England Journal of Medicine, the PROPEL Study found that an intensive healthy lifestyle intervention—which included health coaches embedded in primary care practices working with patients to develop healthy habits—resulted in patients losing significantly more weight than those who received usual care from their primary care clinics, and they kept more weight off at two years later. The results show that successful weight loss can be achieved in primary care settings in a highly underserved population who have significant barriers to obtaining health care services.
Study Compares Treatments for Pediatric Appendicitis
More than 70,000 children in the United States have surgery each year to treat appendicitis. As reported in JAMA, a PCORI-funded study found that among children with uncomplicated appendicitis, nonsurgical treatment with antibiotics was successful in more than half of those patients, and compared with surgery initiated shortly after hospital admission, was associated with significantly fewer disability days. However, the results after one year did not meet the threshold success rate specified at the outset of the study.