This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
PCORI in the Literature
Study Finds Two Types of Anesthesia Safe, Effective for Hip Fracture Surgery
Every year, many of the 250,000 people who have surgery for hip fracture in the United States receive general anesthesia, but the use of regional anesthesia injected into the spine is rapidly increasing. A PCORI-funded randomized trial led by researchers at the University of Pennsylvania found that the two approaches are equally safe and effective. Published in the New England Journal of Medicine, the study of 1,600 patients 50 and older at 46 hospitals across the United States and Canada found rates of survival, ability to walk, and post-operative delirium were similar for patients who had either anesthesia. The results could facilitate decision making about which option best fits a patient’s preferences.
Informing Treatment of Juvenile Arthritis
Clinicians and patients have been uncertain about the optimal time to start biologics for polyarticular juvenile idiopathic arthritis (pJIA). However, results from a PCORI-funded study, published in Arthritis & Rheumatology, provide useful new evidence about first-line treatment options for this disease. Researchers compared the effectiveness of three treatment approaches among 400 children with pJIA. The approaches included starting patients on a non-biologic disease-modifying antirheumatic drug (DMARD) only, starting patients with a DMARD and a biologic medication, and starting patients with a biologic only. After one year, the approaches did not differ significantly in achieving clinically inactive disease without the use of glucorticoids, and patients reported decreased pain interference levels and increased mobility with all three approaches.